Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Stojković, Marija [VerfasserIn]  |
| Mickan, Christina [VerfasserIn]  |
| Weber, Tim [VerfasserIn]  |
| Junghanss, Thomas [VerfasserIn]  |
Titel: | Pitfalls in diagnosis and treatment of alveolar echinococcosis |
Titelzusatz: | a sentinel case series |
Verf.angabe: | M. Stojkovic, C. Mickan, TF Weber, T. Junghanss |
E-Jahr: | 2015 |
Jahr: | December 31, 2015 |
Fussnoten: | Gesehen am 23.06.2020 |
Titel Quelle: | Enthalten in: BMJ open gastroenterology |
Ort Quelle: | London : BMJ Publishing Group, 2014 |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 2(2015,1) Artikel-Nummer e000036, 6 Seiten |
ISSN Quelle: | 2054-4774 |
Abstract: | Background Alveolar echinococcosis (AE) is a neglected zoonosis presenting with focal liver lesions (FLL) with a wide range of imaging patterns resembling benign as well as malignant FLLs. Complementary serology and histopathology may be misleading. - Objective The objective of our study is to highlight pitfalls leading to wrong diagnoses and harmful interventions in patients with AE. - Design This retrospective sentinel case series analyses diagnostic and treatment data of patients with confirmed AE. - Results 80 patients treated between 1999 and 2014 were included in the study. In 26/80 patients treatment decisions were based on a wrong diagnosis. AE was mistaken for cystic echinococcosis (CE) in 12/26 patients followed by cholangiocellular carcinoma (CCA) in 5/26 patients; 61/80 patients had predominantly infiltrative liver lesions and 19/80 patients had a predominantly pseudocystic radiological presentation. Serology correctly differentiated between Echinococcus multilocularis and Echinococcus granulosus in 53/80 patients. Histopathology reports attributed the right Echinococcus species in 25/58 patients but failed to differentiate E. multilocularis from E. granulosus in 25/58 patients. Although contraindicated in AE 8/25 patients treated surgically had instillation of a protoscolicidal agent intraoperatively. One of the eight patients developed toxic cholangitis and liver failure and died 1 year after liver transplantation. - Conclusions Misclassification of AE leads to a critical delay in growth inhibiting benzimidazole treatment, surgical overtreatment and bares the risk of liver failure if protoscolicidal agents are instilled in AE pseudocysts. |
DOI: | doi:10.1136/bmjgast-2015-000036 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1136/bmjgast-2015-000036 |
| Volltext: https://bmjopengastro.bmj.com/content/2/1/e000036 |
| DOI: https://doi.org/10.1136/bmjgast-2015-000036 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | HEPATOBILIARY PATHOLOGY |
| HEPATOBILIARY RADIOLOGY |
| INFECTIOUS DISEASE |
K10plus-PPN: | 1701983087 |
Verknüpfungen: | → Zeitschrift |
Pitfalls in diagnosis and treatment of alveolar echinococcosis / Stojković, Marija [VerfasserIn]; December 31, 2015 (Online-Ressource)
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