Targeting of γ-tubulin complexes to microtubule organizing centers

• Verfasst von: Lin, Dennis Tien-chen [VerfasserIn]
• Verfasst von: Neuner, Annett [VerfasserIn]
• Verfasst von: Schiebel, Elmar [VerfasserIn]
• Titel: Targeting of γ-tubulin complexes to microtubule organizing centers
• Titelzusatz: conservation and divergence
• Verf.angabe: Tien-chen Lin, Annett Neuner, and Elmar Schiebel
• Jahr: 2015
• Jahr des Originals: 2014
• Umfang: 12 S.
• Fussnoten: Available online 24 December 2014 ; Gesehen am 24.06.2020
• Titel Quelle: Enthalten in: Trends in cell biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1991
• Jahr Quelle: 2015
• Band/Heft Quelle: 25(2015), 5, Seite 296-307
• ISSN Quelle: 1879-3088
• DOI: doi:10.1016/j.tcb.2014.12.002
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: centrosome
• Sach-SW: gamma-tubulin complex
• Sach-SW: microtubule
• Sach-SW: mitotic spindle
• Sach-SW: spindle pole body
• K10plus-PPN: 1702027171

Abstract

Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. γ-TuC recruiting factors not only target the γ-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing γ-tubulin ring complexes (γ-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by γ-tubulin small complex (γ-TuSC) receptors. Moreover, we discuss the emergence of γ-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly.