Oxidatively damaged DNA/RNA and 8-isoprostane levels are associated with the development of type 2 diabetes at older age

• Verfasst von: Schöttker, Ben [VerfasserIn]
• Verfasst von: Xuan, Yang [VerfasserIn]
• Verfasst von: Gao, Xin [VerfasserIn]
• Verfasst von: Anusruti, Ankita [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Oxidatively damaged DNA/RNA and 8-isoprostane levels are associated with the development of type 2 diabetes at older age
• Titelzusatz: results from a large cohort study
• Verf.angabe: Ben Schöttker, Yang Xuan, Xīn Gào, Ankita Anusruti and Hermann Brenner
• Jahr: 2020
• Umfang: 7 S.
• Teil: volume:43
• Teil: year:2020
• Teil: number:1
• Teil: pages:130-136
• Teil: extent:7
• Fussnoten: Gesehen am 24.06.2020
• Titel Quelle: Enthalten in: Diabetes care
• Ort Quelle: Alexandria, Va. : Assoc., 1978
• Jahr Quelle: 2020
• Band/Heft Quelle: 43(2020), 1, Seite 130-136
• ISSN Quelle: 1935-5548
• DOI: doi:10.2337/dc19-1379
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1702033708

Abstract

OBJECTIVE Oxidative stress is believed to play an important role in the pathophysiology of type 2 diabetes, but the few cohort studies that have assessed the association of oxidative stress biomarkers with type 2 diabetes incidence were small and reported inconclusive results. - RESEARCH DESIGN AND METHODS We examined the associations of urinary oxidized guanine/guanosine (OxGua) levels (a biomarker of DNA/RNA oxidation) and urinary 8-isoprostane levels (a biomarker of lipid peroxidation) with type 2 diabetes incidence in 7,828 individuals initially without diabetes from a population-based German cohort study with 14 years of follow-up. Hazard ratios (HRs) (95% CIs) per 1 SD were obtained using multivariable-adjusted Cox proportional hazards regression models. - RESULTS In the total population, weak but statistically significant associations with type 2 diabetes incidence were observed for OxGua levels (HR [95% CI] per 1 SD 1.05 [1.01; 1.09]) and 8-isoprostane levels (1.04 [1.00; 1.09]). Stratified analyses showed that associations of both biomarkers with type 2 diabetes incidence were absent in the youngest age-group (50-59 years) and strongest in the oldest age-group (65-75 years) of the cohort, with HR of OxGua levels 1.14 (1.05; 1.23) per 1 SD and of 8-isoprostane levels 1.22 (1.02; 1.45) per 1 SD. - CONCLUSIONS These results from a large cohort study support suggestions that an imbalanced redox system contributes to the development of type 2 diabetes but suggest that this association becomes clinically apparent at older ages only, possibly as a result of reduced cellular repair capacity.