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Verfasst von:Schlüter, Annabelle [VerfasserIn]   i
 Aksan, Bahar [VerfasserIn]   i
 Diem, Ricarda [VerfasserIn]   i
 Fairless, Richard [VerfasserIn]   i
 Mauceri, Daniela [VerfasserIn]   i
Titel:VEGFD protects retinal ganglion cells and, consequently, capillaries against excitotoxic injury
Verf.angabe:Annabelle Schlüter, Bahar Aksan, Ricarda Diem, Richard Fairless, and Daniela Mauceri
Jahr:2020
Jahr des Originals:2019
Umfang:19 S.
Fussnoten:Available online 25 December 2019 ; Gesehen am 24.06.2020
Titel Quelle:Enthalten in: Molecular therapy. Methods & clinical development
Ort Quelle:New York, NY : Nature Publishing Group, 2014
Jahr Quelle:2020
Band/Heft Quelle:17(2020), Seite 281-299
ISSN Quelle:2329-0501
Abstract:In the central nervous system, neurons and the vasculature influence each other. While it is well described that a functional vascular system is trophic to neurons and that vascular damage contributes to neurodegeneration, the opposite scenario in which neural damage might impact the microvasculature is less defined. In this study, using an in vivo excitotoxic approach in adult mice as a tool to cause specific damage to retinal ganglion cells, we detected subsequent damage to endothelial cells in retinal capillaries. Furthermore, we detected decreased expression of vascular endothelial growth factor D (VEGFD) in retinal ganglion cells. In vivo VEGFD supplementation via neuronal-specific viral-mediated expression or acute intravitreal delivery of the mature protein preserved the structural and functional integrity of retinal ganglion cells against excitotoxicity and, additionally, spared endothelial cells from degeneration. Viral-mediated suppression of expression of the VEGFD-binding receptor VEGFR3 in retinal ganglion cells revealed that VEGFD exerts its protective capacity directly on retinal ganglion cells, while protection of endothelial cells is the result of upheld neuronal integrity. These findings suggest that VEGFD supplementation might be a novel, clinically applicable approach for neuronal and vascular protection.
DOI:doi:10.1016/j.omtm.2019.12.009
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.omtm.2019.12.009
 Volltext: http://www.sciencedirect.com/science/article/pii/S2329050119301585
 DOI: https://doi.org/10.1016/j.omtm.2019.12.009
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:capillaries
 endothelial cells
 excitotoxicity
 neuroprotection
 neurovascular
 recombinant proteins
 retina
 retinal ganglion cells
 VEGFD
 VEGFR3
K10plus-PPN:1702041603
Verknüpfungen:→ Zeitschrift

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