Nuclear-Overhauser-enhanced MR imaging of 31P-containing metabolites

• Verfasst von: Rink, Kristian [VerfasserIn]
• Verfasst von: Berger, Moritz C. [VerfasserIn]
• Verfasst von: Korzowski, Andreas [VerfasserIn]
• Verfasst von: Breithaupt, Mathies [VerfasserIn]
• Verfasst von: Biller, Armin [VerfasserIn]
• Verfasst von: Bachert, Peter [VerfasserIn]
• Verfasst von: Nagel, Armin Michael [VerfasserIn]
• Titel: Nuclear-Overhauser-enhanced MR imaging of 31P-containing metabolites
• Titelzusatz: multipoint-Dixon vs. frequency-selective excitation
• Verf.angabe: Kristian Rink, Moritz C. Berger, Andreas Korzowski, Mathies Breithaupt, Armin Biller, Peter Bachert, Armin M. Nagel
• E-Jahr: 2015
• Jahr: [2015]
• Umfang: 9 S.
• Illustrationen: Illustrationen, Diagramme
• Fussnoten: Die 31 im Titel ist hochgestellt ; Gesehen am 25.06.2020
• Titel Quelle: Enthalten in: Magnetic resonance imaging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1982
• Jahr Quelle: 2015
• Band/Heft Quelle: 33(2015), 10, Seite 1281-1289
• ISSN Quelle: 1873-5894
• DOI: doi:10.1016/j.mri.2015.07.017
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Dixon
• Sach-SW: High-energy phosphate metabolism
• Sach-SW: Nuclear Overhauser effect
• Sach-SW: P MRI
• Sach-SW: Steady-state free precession (SSFP)
• K10plus-PPN: 1702142590

Abstract

The purpose of this study is to develop nuclear-Overhauser-enhanced (NOE) [1H]-31P magnetic resonance imaging (MRI) based on 3D fully-balanced steady-state free precession (fbSSFP). Therefore, two implementations of a 3D fbSSFP sequence are compared using frequency-selective excitation (FreqSel) and multipoint-Dixon (MP-Dixon). 31P-containing model solutions and four healthy volunteers were examined at field strengths of B0=3T and 7T. Maps of the distribution of phosphocreatine (PCr), inorganic phosphate (Pi), and adenosine 5´-triphosphate (ATP) in the human calf were obtained with an isotropic resolution of 1.5cm (1.0cm) in an acquisition time of 5min (10min). NOE-pulses had the highest impact on the PCr acquisitions enhancing the signal up to (82 ± 13) % at 3T and up to (37 ± 9) % at 7T. An estimation of the level of PCr in muscle tissue from [1H]-31P MRI data yielded a mean value of (33 ± 8) mM. In conclusion, direct [1H]-31P imaging using FreqSel as well as MP-Dixon is possible in clinically feasible acquisition times. FreqSel should be preferred for measurements where only a single metabolite resonance is considered. MP-Dixon performs better in terms of SNR if a larger spectral width is of interest.