| |  Online-Ressource |
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| Verfasst von: | Oweira, Hani [VerfasserIn]  |
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| | Lahdou, Imad [VerfasserIn] |
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| | Daniel, Volker [VerfasserIn] |
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| | Hofer, Stefan [VerfasserIn] |
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| | Mieth, Markus [VerfasserIn] |
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| | Schmidt, Jan [VerfasserIn] |
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| | Schemmer, Peter [VerfasserIn] |
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| | Opelz, Gerhard [VerfasserIn] |
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| | Mehrabi, Arianeb [VerfasserIn] |
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| | Sadeghi, Mahmoud [VerfasserIn] |
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| Titel: | Early post-transplant neopterin associated with one year survival and bacteremia in liver transplant recipients |
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| Verf.angabe: | Hani Oweira, Imad Lahdou, Volker Daniel, Stefan Hofer, Markus Mieth, Jan Schmidt, Peter Schemmer, Gerhard Opelz, Arianeb Mehrabi, Mahmoud Sadeghi |
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| Jahr: | 2016 |
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| Umfang: | 6 S. |
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| Fussnoten: | Published online 12 November 2015 ; Gesehen am 26.06.2020 |
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| Titel Quelle: | Enthalten in: Human immunology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 77(2016), 1, Seite 115-120 |
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| ISSN Quelle: | 1879-1166 |
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| Abstract: | Bacterial infections are the most common complications, and the major cause of mortality after liver transplantation (Tx). Neopterin, a marker of immune activation, is produced in monocyte/macrophages in response to inflammation. The aim of our study was to investigate whether early post-operation serum levels of neopterin were associated with post-transplant bacteremia and mortality in liver transplant recipients. We studied 162 of 262 liver Tx patients between January 2008 and February 2011 of whom pre- and early post-Tx sera samples were available. Pre- and early post-operative risk factors of infection and mortality were evaluated in 45 bacteremic patients and 117 non-bacteremic patients. During one-year follow-up, 28 of 262 patients died because of graft failure, septicemia and other diseases. Post-Tx serum neopterin on day 10 (p<0.001) were significantly higher in bacteriemic patients than in patients without bacteremia. Logistic regression analyses showed that day 10 post-Tx neopterin serum level ⩾40nmol/l has a predictive value (OR=6.86: p<0.001) for bacteremia and mortality (OR=3.47: p=0.021). Our results suggest that early post-Tx neopterin serum levels are very sensitive predictive markers of one-year post-Tx bacteremia and mortality in liver Tx recipients. |
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| DOI: | doi:10.1016/j.humimm.2015.11.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.humimm.2015.11.003 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S019888591500556X |
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| | DOI: https://doi.org/10.1016/j.humimm.2015.11.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Liver |
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| | Neopterin |
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| | Outcome |
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| | Transplantation |
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| K10plus-PPN: | 1702637697 |
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| Verknüpfungen: | → Zeitschrift |
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Early post-transplant neopterin associated with one year survival and bacteremia in liver transplant recipients / Oweira, Hani [VerfasserIn]; 2016 (Online-Ressource)
