| Online-Ressource |
Verfasst von: | Oweira, Hani [VerfasserIn]  |
| Lahdou, Imad [VerfasserIn]  |
| Daniel, Volker [VerfasserIn]  |
| Hofer, Stefan [VerfasserIn]  |
| Mieth, Markus [VerfasserIn]  |
| Schmidt, Jan [VerfasserIn]  |
| Schemmer, Peter [VerfasserIn]  |
| Opelz, Gerhard [VerfasserIn]  |
| Mehrabi, Arianeb [VerfasserIn]  |
| Sadeghi, Mahmoud [VerfasserIn]  |
Titel: | Early post-transplant neopterin associated with one year survival and bacteremia in liver transplant recipients |
Verf.angabe: | Hani Oweira, Imad Lahdou, Volker Daniel, Stefan Hofer, Markus Mieth, Jan Schmidt, Peter Schemmer, Gerhard Opelz, Arianeb Mehrabi, Mahmoud Sadeghi |
Jahr: | 2016 |
Umfang: | 6 S. |
Fussnoten: | Published online 12 November 2015 ; Gesehen am 26.06.2020 |
Titel Quelle: | Enthalten in: Human immunology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 77(2016), 1, Seite 115-120 |
ISSN Quelle: | 1879-1166 |
Abstract: | Bacterial infections are the most common complications, and the major cause of mortality after liver transplantation (Tx). Neopterin, a marker of immune activation, is produced in monocyte/macrophages in response to inflammation. The aim of our study was to investigate whether early post-operation serum levels of neopterin were associated with post-transplant bacteremia and mortality in liver transplant recipients. We studied 162 of 262 liver Tx patients between January 2008 and February 2011 of whom pre- and early post-Tx sera samples were available. Pre- and early post-operative risk factors of infection and mortality were evaluated in 45 bacteremic patients and 117 non-bacteremic patients. During one-year follow-up, 28 of 262 patients died because of graft failure, septicemia and other diseases. Post-Tx serum neopterin on day 10 (p<0.001) were significantly higher in bacteriemic patients than in patients without bacteremia. Logistic regression analyses showed that day 10 post-Tx neopterin serum level ⩾40nmol/l has a predictive value (OR=6.86: p<0.001) for bacteremia and mortality (OR=3.47: p=0.021). Our results suggest that early post-Tx neopterin serum levels are very sensitive predictive markers of one-year post-Tx bacteremia and mortality in liver Tx recipients. |
DOI: | doi:10.1016/j.humimm.2015.11.003 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.humimm.2015.11.003 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S019888591500556X |
| DOI: https://doi.org/10.1016/j.humimm.2015.11.003 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Liver |
| Neopterin |
| Outcome |
| Transplantation |
K10plus-PPN: | 1702637697 |
Verknüpfungen: | → Zeitschrift |
Early post-transplant neopterin associated with one year survival and bacteremia in liver transplant recipients / Oweira, Hani [VerfasserIn]; 2016 (Online-Ressource)