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| Verfasst von: | Noormohammadi, Alireza [VerfasserIn]  |
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| | Khodakarami, Amirabbas [VerfasserIn] |
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| | Gutierrez-Garcia, Ricardo [VerfasserIn] |
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| | Lee, Hyun Ju [VerfasserIn] |
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| | Koyuncu, Seda [VerfasserIn] |
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| | König, Tim [VerfasserIn] |
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| | Schindler, Christina [VerfasserIn] |
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| | Saez, Isabel [VerfasserIn] |
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| | Fatima, Azra [VerfasserIn] |
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| | Dieterich, Christoph [VerfasserIn] |
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| | Vilchez, David [VerfasserIn] |
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| Titel: | Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan |
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| Verf.angabe: | Alireza Noormohammadi, Amirabbas Khodakarami, Ricardo Gutierrez-Garcia, Hyun Ju Lee, Seda Koyuncu, Tim König, Christina Schindler, Isabel Saez, Azra Fatima, Christoph Dieterich & David Vilchez |
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| E-Jahr: | 2016 |
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| Jahr: | 28 Nov 2016 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 26.06.2020 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 7(2016) Artikel-Nummer 13649, 15 Seiten |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Human embryonic stem cells can replicate indefinitely while maintaining their undifferentiated state and, therefore, are immortal in culture. This capacity may demand avoidance of any imbalance in protein homeostasis (proteostasis) that would otherwise compromise stem cell identity. Here we show that human pluripotent stem cells exhibit enhanced assembly of the TRiC/CCT complex, a chaperonin that facilitates the folding of 10% of the proteome. We find that ectopic expression of a single subunit (CCT8) is sufficient to increase TRiC/CCT assembly. Moreover, increased TRiC/CCT complex is required to avoid aggregation of mutant Huntingtin protein. We further show that increased expression of CCT8 in somatic tissues extends Caenorhabditis elegans lifespan in a TRiC/CCT-dependent manner. Ectopic expression of CCT8 also ameliorates the age-associated demise of proteostasis and corrects proteostatic deficiencies in worm models of Huntington’s disease. Our results suggest proteostasis is a common principle that links organismal longevity with hESC immortality. |
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| DOI: | doi:10.1038/ncomms13649 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/ncomms13649 |
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| | Volltext: https://www.nature.com/articles/ncomms13649 |
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| | DOI: https://doi.org/10.1038/ncomms13649 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1702647528 |
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| Verknüpfungen: | → Zeitschrift |
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Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan / Noormohammadi, Alireza [VerfasserIn]; 28 Nov 2016 (Online-Ressource)
