| |  Online-Ressource |
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| Verfasst von: | Wesołowska, Agata [VerfasserIn]  |
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| | Borst, L. [VerfasserIn] |
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| | Dalgaard, M. D. [VerfasserIn] |
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| | Yadav, R. [VerfasserIn] |
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| | Rasmussen, K. K. [VerfasserIn] |
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| | Wehner, P. S. [VerfasserIn] |
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| | Rasmussen, M. [VerfasserIn] |
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| | Ørntoft, T. F. [VerfasserIn] |
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| | Nordentoft, I. [VerfasserIn] |
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| | Köhler, Rolf [VerfasserIn] |
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| | Bartram, Claus R. [VerfasserIn] |
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| | Schrappe, M. [VerfasserIn] |
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| | Sicheritz-Ponten, T. [VerfasserIn] |
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| | Gautier, L. [VerfasserIn] |
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| | Marquart, H. [VerfasserIn] |
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| | Madsen, H. O. [VerfasserIn] |
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| | Brunak, S. [VerfasserIn] |
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| | Stanulla, M. [VerfasserIn] |
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| | Gupta, R. [VerfasserIn] |
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| | Schmiegelow, K. [VerfasserIn] |
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| Titel: | Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients |
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| Verf.angabe: | A. Wesołowska-Andersen, L. Borst, M.D. Dalgaard, R. Yadav, K.K. Rasmussen, P.S. Wehner, M. Rasmussen, T.F. Ørntoft, I. Nordentoft, R. Koehler, C.R. Bartram, M. Schrappe, T. Sicheritz-Ponten, L. Gautier, H. Marquart, H.O. Madsen, S. Brunak, M. Stanulla, R. Gupta and K. Schmiegelow |
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| Jahr: | 2015 |
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| Jahr des Originals: | 2014 |
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| Umfang: | 7 S. |
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| Fussnoten: | advance online publication, 25 July 2014 ; Gesehen am 30.06.2020 |
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| Titel Quelle: | Enthalten in: Leukemia |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 29(2015), 2, Seite 297-303 |
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| ISSN Quelle: | 1476-5551 |
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| Abstract: | Childhood acute lymphoblastic leukemia survival approaches 90%. New strategies are needed to identify the 10-15% who evade cure. We applied targeted, sequencing-based genotyping of 25 000 to 34 000 preselected potentially clinically relevant single-nucleotide polymorphisms (SNPs) to identify host genome profiles associated with relapse risk in 352 patients from the Nordic ALL92/2000 protocols and 426 patients from the German Berlin-Frankfurt-Munster (BFM) ALL2000 protocol. Patients were enrolled between 1992 and 2008 (median follow-up: 7.6 years). Eleven cross-validated SNPs were significantly associated with risk of relapse across protocols. SNP and biologic pathway level analyses associated relapse risk with leukemia aggressiveness, glucocorticosteroid pharmacology/response and drug transport/metabolism pathways. Classification and regression tree analysis identified three distinct risk groups defined by end of induction residual leukemia, white blood cell count and variants in myeloperoxidase (MPO), estrogen receptor 1 (ESR1), lamin B1 (LMNB1) and matrix metalloproteinase-7 (MMP7) genes, ATP-binding cassette transporters and glucocorticosteroid transcription regulation pathways. Relapse rates ranged from 4% (95% confidence interval (CI): 1.6-6.3%) for the best group (72% of patients) to 76% (95% CI: 41-90%) for the worst group (5% of patients, P<0.001). Validation of these findings and similar approaches to identify SNPs associated with toxicities may allow future individualized relapse and toxicity risk-based treatments adaptation. |
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| DOI: | doi:10.1038/leu.2014.205 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/leu.2014.205 |
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| | Volltext: https://www.nature.com/articles/leu2014205 |
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| | DOI: https://doi.org/10.1038/leu.2014.205 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1702950093 |
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| Verknüpfungen: | → Zeitschrift |
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Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients / Wesołowska, Agata [VerfasserIn]; 2015 (Online-Ressource)
