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Status: Bibliographieeintrag

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Verfasst von:Weymann, Alexander [VerfasserIn]   i
 Patil, Nikhil Prakash [VerfasserIn]   i
 Sabashnikov, Anton [VerfasserIn]   i
 Mohite, Prashant N. [VerfasserIn]   i
 Sáez, Diana García [VerfasserIn]   i
 Amrani, Mohamed [VerfasserIn]   i
 Bahrami, Toufan [VerfasserIn]   i
 Robertis, Fabio De [VerfasserIn]   i
 Wahlers, Thorsten [VerfasserIn]   i
 Banner, Nicholas R. [VerfasserIn]   i
 Popov, Aron-Frederik [VerfasserIn]   i
 Simon, André R. [VerfasserIn]   i
Titel:Gender differences in continuous-flow left ventricular assist device therapy as a bridge to transplantation
Titelzusatz:a risk-adjusted comparison using a propensity score-matching analysis
Verf.angabe:Alexander Weymann, Nikhil Prakash Patil, Anton Sabashnikov, Prashant N. Mohite, Diana García Sáez, Mohamed Amrani, Toufan Bahrami, Fabio De Robertis, Thorsten Wahlers, Nicholas R. Banner, Aron-Frederik Popov, and André R. Simon
Jahr:2015
Umfang:8 S.
Fussnoten:First published: 29 August 2014 ; Gesehen am 01.07.2020
Titel Quelle:Enthalten in: Artificial organs
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1977
Jahr Quelle:2015
Band/Heft Quelle:39(2015), 3, Seite 212-219
ISSN Quelle:1525-1594
Abstract:The purpose of this study was to evaluate gender differences regarding outcome after continuous-flow left ventricular assist device (cfLVAD) implantation. The study was a retrospective review of prospectively collected data. Included were 24 consecutive female cfLVAD recipients and 24 male recipients (62.5% HeartMate II, 37.5% HeartWare) who received their devices between July 2007 and May 2013. Subjects were matched using propensity score analysis based on age, diagnosis, body surface area, preoperative mechanical circulatory support, heart failure severity score (INTERMACS class), and comorbidities. Female patients were significantly sicker before operation. After propensity score matching, there were no statistically significant differences in demographics or clinical baseline characteristics between male and female LVAD recipients. Also, there was a trend towards a longer postoperative intensive care unit stay in the female group (median 9 days [interquartile range 5-17] versus 15 days [interquartile range 8-33]; P < 0.061) and higher postoperative bilirubin values (median 14 mmol/L [interquartile range 10-17] versus 21 mmol/L [interquartile range 13-30]). However, there were no significant differences between the two groups in terms of outcome (P < 0.569). The overall survival was comparable between the two groups (log rank P < 0.389). Half (50%) of female patients required inotropic support for more than 7 days compared with 21.7% in the male group (P < 0.048). Half (50%) of female recipients required short-term postoperative right ventricular assist device implantation compared with 16.7% in the male group (P < 0.014). In conclusion, cfLVAD implantation as a bridge to transplantation is associated with longer duration of inotropic support and higher requirement for postoperative mechanical right ventricular support in women with similar survival rates. Further studies are required to identify additional demographic and clinical factors that modulate outcomes and will enhance the ability to risk-stratify cfLVAD recipients.
DOI:doi:10.1111/aor.12361
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1111/aor.12361
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/aor.12361
 DOI: https://doi.org/10.1111/aor.12361
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Bridge to recovery
 Bridge to transplantation
 Continuous-flow left ventricular assist device
 Gender differences
K10plus-PPN:170300437X
Verknüpfungen:→ Zeitschrift

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