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Verfasst von:Magalhães Martins, Paulo [VerfasserIn]   i
 Dal Bello, Riccardo [VerfasserIn]   i
 Ackermann, Benjamin [VerfasserIn]   i
 Brons, Stephan [VerfasserIn]   i
 Hermann, German [VerfasserIn]   i
 Kihm, Thomas [VerfasserIn]   i
 Seco, Joao [VerfasserIn]   i
Titel:PIBS
Titelzusatz:Proton and ion beam spectroscopy for in vivo measurements of oxygen, carbon, and calcium concentrations in the human body
Verf.angabe:Paulo Magalhaes Martins, Riccardo Dal Bello, Benjamin Ackermann, Stephan Brons, German Hermann, Thomas Kihm & Joao Seco
E-Jahr:2020
Jahr:April 24, 2020
Umfang:15 S.
Fussnoten:Gesehen am 02.07.2020
Titel Quelle:Enthalten in: Scientific reports
Ort Quelle:[London] : Macmillan Publishers Limited, part of Springer Nature, 2011
Jahr Quelle:2020
Band/Heft Quelle:10(2020) Artikel-Nummer 7007, 15 Seiten
ISSN Quelle:2045-2322
Abstract:Proton and ion beam therapy has proven to benefit tumour control with lower side-effects, mostly in paediatrics. Here we demonstrate a feasible technique for proton and ion beam spectroscopy (PIBS) capable of determining the elemental compositions of the irradiated tissues during particle therapy. This follows the developments in prompt gamma imaging for online range verification and the inheritance from prompt gamma neutron activation analysis. Samples of water solutions were prepared to emulate varying oxygen and carbon concentrations. The irradiation of those samples and other tissue surrogate inserts by protons and ion beams under clinical conditions clearly showed a logarithmic relationship between the target elemental composition and the prompt gamma production. This finding is in line with the known logarithmic dependence of the pH with the proton molar concentration. Elemental concentration changes of 1% for calcium and 2% for oxygen in adipose, brain, breast, liver, muscle and bone-related tissue surrogates were clearly identified. Real-time in vivo measurements of oxygen, carbon and calcium concentrations will be evaluated in a pre-clinical and clinical environment. This technique should have an important impact in the assessment of tumour hypoxia over the course of several treatment fractions and the tracking of calcifications in brain metastases.
DOI:doi:10.1038/s41598-020-63215-0
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/s41598-020-63215-0
 DOI: https://doi.org/10.1038/s41598-020-63215-0
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:analysis facility
 camera
 hydrogen
 intracellular ph
 invivo
 neutron-activation analysis
 nitrogen
 prompt-gamma emission
 range verification
 therapy
K10plus-PPN:1703273729
Verknüpfungen:→ Zeitschrift

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