| |  Online-Ressource |
|---|
| Verfasst von: | Mattos, Eduardo P. de [VerfasserIn]  |
|---|
| | Wentink, Anne [VerfasserIn] |
|---|
| | Nussbaum, Carmen [VerfasserIn] |
|---|
| | Hansen, Christian [VerfasserIn] |
|---|
| | Bergink, Steven [VerfasserIn] |
|---|
| | Melki, Ronald [VerfasserIn] |
|---|
| | Kampinga, Harm H. [VerfasserIn] |
|---|
| Titel: | Protein quality control pathways at the crossroad of synucleinopathies |
|---|
| Verf.angabe: | Eduardo P. De Mattos, Anne Wentink, Carmen Nussbaum-Krammer, Christian Hansen, Steven Bergink, Ronald Melki, Harm H. Kampinga |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 2 January 2020 |
|---|
| Umfang: | 14 S. |
|---|
| Fussnoten: | Gesehen am 02.07.2020 |
|---|
| Titel Quelle: | Enthalten in: Journal of Parkinson's Disease |
|---|
| Ort Quelle: | Amsterdam : IOS Press, 2011 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 10(2020), 2, Seite 369-382 |
|---|
| ISSN Quelle: | 1877-718X |
|---|
| Abstract: | The pathophysiology of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and many others converge at alpha-synuclein (alpha-Syn) aggregation. Although it is still not entirely clear what precise biophysical processes act as triggers, cumulative evidence points towards a crucial role for protein quality control (PQC) systems in modulating alpha-Syn aggregation and toxicity. These encompass distinct cellular strategies that tightly balance protein production, stability, and degradation, ultimately regulating alpha-Syn levels. Here, we review the main aspects of alpha-Syn biology, focusing on the cellular PQC components that are at the heart of recognizing and disposing toxic, aggregate-prone alpha-Syn assemblies: molecular chaperones and the ubiquitin-proteasome system and autophagy-lysosome pathway, respectively. A deeper understanding of these basic protein homeostasis mechanisms might contribute to the development of new therapeutic strategies envisioning the prevention and/or enhanced degradation of alpha-Syn aggregates. |
|---|
| DOI: | doi:10.3233/JPD-191790 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3233/JPD-191790 |
|---|
| | DOI: https://doi.org/10.3233/JPD-191790 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Alpha-synuclein |
|---|
| | autophagy |
|---|
| | chaperone-mediated autophagy |
|---|
| | fibril formation |
|---|
| | glial cytoplasmic inclusions |
|---|
| | heat-shock proteins |
|---|
| | impairs macroautophagy |
|---|
| | lysosomal degradation |
|---|
| | molecular chaperones |
|---|
| | multiple system atrophy |
|---|
| | mutant alpha-synuclein |
|---|
| | parkinsons-disease |
|---|
| | protein aggregation |
|---|
| | protein homeostasis |
|---|
| | synucleinopathies |
|---|
| | ubiquitin-proteasome system |
|---|
| K10plus-PPN: | 1703321596 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Protein quality control pathways at the crossroad of synucleinopathies / Mattos, Eduardo P. de [VerfasserIn]; 2 January 2020 (Online-Ressource)
