Closing the gap

• Verfasst von: Carnesecchi, Julie [VerfasserIn]
• Verfasst von: Lohmann, Ingrid [VerfasserIn]
• Titel: Closing the gap
• Titelzusatz: a roadmap to single-cell regulatory genomics
• Verf.angabe: Julie Carnesecchi & Ingrid Lohmann
• E-Jahr: 2020
• Jahr: May 2020
• Umfang: 3 S.
• Fussnoten: Gesehen am 02.07.2020
• Titel Quelle: Enthalten in: Molecular systems biology
• Ort Quelle: Heidelberg : EMBO Press, 2005
• Jahr Quelle: 2020
• Band/Heft Quelle: 16(2020,5) Artikel-Nummer e9497, 3 Seiten
• ISSN Quelle: 1744-4292
• DOI: doi:10.15252/msb.20209497
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1703397673

Abstract

Studying the spatiotemporal control of gene regulatory networks at the single-cell level is still a challenge, yet it is key to understanding the mechanisms driving cellular identity. In their recent study, Aerts and colleagues (Gonzalez-Blas et al, 2020) develop a new strategy to spatially map and integrate single-cell transcriptome and epigenome profiles in the Drosophila eye-antennal disc and to deduce in each cell precise enhancer-to-gene activity relationships. This opens a new era in the transcriptional regulation field, as it allows extracting from each of the thousands of cells forming a tissue the critical features driving their identity, from enhancer sequences to transcription factors to gene regulatory networks.