Preanalytics in lung cancer

• Verfasst von: Warth, Arne [VerfasserIn]
• Verfasst von: Muley, Thomas [VerfasserIn]
• Verfasst von: Meister, Michael [VerfasserIn]
• Verfasst von: Weichert, Wilko [VerfasserIn]
• Titel: Preanalytics in lung cancer
• Verf.angabe: Arne Warth, Thomas Muley, Michael Meister, Wilko Weichert
• Jahr: 2015
• Umfang: 14 S.
• Teil: year:2015
• Teil: pages:71-84
• Teil: extent:14
• Fussnoten: Gesehen am 06.07.2020
• Titel Quelle: Enthalten in: Pre-analytics of pathological specimens in oncology
• Ort Quelle: Cham : Springer, 2015
• Jahr Quelle: 2015
• Band/Heft Quelle: (2015), Seite 71-84
• ISBN Quelle: 978-3-319-13957-9
• DOI: doi:10.1007/978-3-319-13957-9_8
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cell Block
• Sach-SW: Cytology Specimen
• Sach-SW: Routine Diagnostics
• Sach-SW: Small Cell Lung Cancer Patient
• Sach-SW: Tumor Cell Content
• K10plus-PPN: 1703729331

Abstract

Preanalytic sampling techniques and preparation of tissue specimens strongly influence analytical results in lung tissue diagnostics both on the morphological but also on the molecular level. However, in contrast to analytics where tremendous achievements in the last decade have led to a whole new portfolio of test methods, developments in preanalytics have been minimal. This is specifically unfortunate in lung cancer, where usually only small amounts of tissue are at hand and optimization in all processing steps is mandatory in order to increase the diagnostic yield. In the following, we provide a comprehensive overview on some aspects of preanalytics in lung cancer from the method of sampling over tissue processing to its impact on analytical test results. We specifically discuss the role of preanalytics in novel technologies like next-generation sequencing and in the state-of the-art cytology preparations. In addition, we point out specific problems in preanalytics which hamper further developments in the field of lung tissue diagnostics.