| |  Online-Ressource |
|---|
| Verfasst von: | Stocker, Hannah [VerfasserIn]  |
|---|
| | Nabers, Andreas [VerfasserIn] |
|---|
| | Perna, Laura [VerfasserIn] [VerfasserIn] |
|---|
| | Möllers, Tobias [VerfasserIn] |
|---|
| | Rujescu, Dan [VerfasserIn] |
|---|
| | Hartmann, Annette [VerfasserIn] |
|---|
| | Holleczek, Bernd [VerfasserIn] |
|---|
| | Schöttker, Ben [VerfasserIn] |
|---|
| | Gerwert, Klaus [VerfasserIn] |
|---|
| | Brenner, Hermann [VerfasserIn] |
|---|
| Titel: | Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors |
|---|
| Verf.angabe: | Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette Hartmann, Bernd Holleczek, Ben Schöttker, Klaus Gerwert, Hermann Brenner |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 6 January 2020 |
|---|
| Umfang: | 9 S. |
|---|
| Fussnoten: | Gesehen am 07.07.2020 |
|---|
| Titel Quelle: | Enthalten in: Alzheimer's and dementia |
|---|
| Ort Quelle: | Hoboken, NJ : Wiley, 2005 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 16(2020), 2, Seite 283-291 |
|---|
| ISSN Quelle: | 1552-5279 |
|---|
| Abstract: | Introduction: Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of A beta misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD. Methods: Within a community-based cohort, A beta misfolding in plasma measured by immuno-infrared sensor and APOE genotypewere determined at baseline in 770 participants followed over 14 years. Associations between A beta misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed. Results: A beta misfolding was associated with a 23-fold increased odds of clinical AD diagnosis within 14 years. No association was observed with vascular dementia/mixed dementia diagnoses. APOE4-positive participants had a 2.4-fold increased odds of clinical AD diagnosis within 14 years. Discussion: A beta misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD evenmany years before diagnosis in a community-based setting. |
|---|
| DOI: | doi:10.1016/j.jalz.2019.08.189 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jalz.2019.08.189 |
|---|
| | DOI: https://doi.org/10.1016/j.jalz.2019.08.189 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Alzheimer's disease |
|---|
| | Amyloid beta (A beta) |
|---|
| | Amyloid-beta |
|---|
| | Apolipoprotein E (APOE) |
|---|
| | Association workgroups |
|---|
| | Biomarkers |
|---|
| | Blood plasma |
|---|
| | Cerebrospinal-fluid |
|---|
| | Cognitive impairment |
|---|
| | Dementia |
|---|
| | Infrared-sensor |
|---|
| | National institute |
|---|
| | Research framework |
|---|
| | Risk stratification |
|---|
| | Secondary structure |
|---|
| | Vascular dementia |
|---|
| K10plus-PPN: | 1703835301 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors / Stocker, Hannah [VerfasserIn]; 6 January 2020 (Online-Ressource)
