Influence of Current and Previous Smoking on Cancer and Mortality After Kidney Transplantation

• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Verfasst von: Döhler, Bernd [VerfasserIn]
• Titel: Influence of Current and Previous Smoking on Cancer and Mortality After Kidney Transplantation
• Verf.angabe: Gerhard Opelz, MD, and Bernd Döhler, PhD
• Jahr: 2016
• Umfang: 6 S.
• Fussnoten: Gesehen am 07.07.2020
• Titel Quelle: Enthalten in: Transplantation
• Ort Quelle: Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
• Jahr Quelle: 2016
• Band/Heft Quelle: 100(2016), 1, Seite 227-232
• ISSN Quelle: 1534-6080
• DOI: doi:10.1097/TP.0000000000000804
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1703837584

Abstract

Background - Evidence is limited regarding the effect of stopping smoking before kidney transplantation. - Methods - Collaborative Transplant Study data from 46 548 recipients of first kidney transplants (1995-2012) were analyzed to 10 years after transplantation. - Results - Compared with patients who had never smoked (n = 31,462), patients who stopped smoking before transplantation (n = 10,291) only had a modestly increased risk of all-cause graft failure (hazard ratio [HR], 1.1; 95% confidence interval [95% CI], 1.0-1.1; P < 0.001) or death (HR,1.1; 95% CI, 1.0-1.2; P < 0.001) and a similar risk of death-censored graft failure (HR,1.0, 95% CI, 1.0-1.1; P = 0.19), but a 40% increase in death from malignancy (HR, 1.4; 95% CI, 1.2-1.7; P < 0.001). The risk of events was generally markedly higher in patients who continued to smoke (n = 4795) versus those who had stopped. For tumors of the lip, oral cavity and pharynx, digestive organs, respiratory tract, female genitalia and urinary tract, HR values increased significantly from never-smoked to former smokers to current smokers. The risk of respiratory tumors or cervical cancer was approximately halved when smoking was stopped versus continued. - Conclusions - This large series provides clear evidence that patients who stop smoking before transplantation experience substantial benefits, including a substantial reduction in certain types of malignancy.