| |  Online-Ressource |
|---|
| Verfasst von: | Rosenberger, Ina [VerfasserIn]  |
|---|
| | Dimitrakopoulou-Strauss, Antonia [VerfasserIn] |
|---|
| | Dobiasch, Sophie [VerfasserIn] |
|---|
| | Weis, Christian [VerfasserIn] |
|---|
| | Szanyi, Szilard [VerfasserIn] |
|---|
| | Gil-Iceta, L. [VerfasserIn] |
|---|
| | Alonso, E. [VerfasserIn] |
|---|
| | González Esparza, M. [VerfasserIn] |
|---|
| | Gómez-Vallejo, V. [VerfasserIn] |
|---|
| | Szczupak, B. [VerfasserIn] |
|---|
| | Plaza-García, S. [VerfasserIn] |
|---|
| | Mirzaei, S. [VerfasserIn] |
|---|
| | Israel, L. L. [VerfasserIn] |
|---|
| | Bianchessi, S. [VerfasserIn] |
|---|
| | Scanziani, E. [VerfasserIn] |
|---|
| | Lellouche, J. -P. [VerfasserIn] |
|---|
| | Knoll, P. [VerfasserIn] |
|---|
| | Werner, Jens [VerfasserIn] |
|---|
| | Felix, Klaus M. [VerfasserIn] |
|---|
| | Grenacher, L. [VerfasserIn] |
|---|
| | Reese, T. [VerfasserIn] |
|---|
| | Kreuter, J. [VerfasserIn] |
|---|
| | Jiménez-González, M. [VerfasserIn] |
|---|
| Titel: | Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer |
|---|
| Verf.angabe: | I. Rosenberger, A. Strauss, S. Dobiasch, C. Weis, S. Szanyi, L. Gil-Iceta, E. Alonso, M. González Esparza, V. Gómez-Vallejo, B. Szczupak, S. Plaza-García, S. Mirzaei, L. L. Israel, S. Bianchessi, E. Scanziani, J. -P. Lellouche, P. Knoll, J. Werner, K. Felix, L. Grenacher, T. Reese, J. Kreuter, M. Jiménez-González |
|---|
| E-Jahr: | 2015 |
|---|
| Jahr: | 17 July 2015 |
|---|
| Umfang: | 9 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Gesehen am 08.07.2020 |
|---|
| Titel Quelle: | Enthalten in: Journal of controlled release |
|---|
| Ort Quelle: | New York, NY [u.a.] : Elsevier, 1984 |
|---|
| Jahr Quelle: | 2015 |
|---|
| Band/Heft Quelle: | 214(2015), Seite 76-84 |
|---|
| ISSN Quelle: | 1873-4995 |
|---|
| Abstract: | Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography-computer tomography (SPECT-CT), a handheld gamma camera, and magnetic resonance imaging (MRI). |
|---|
| DOI: | doi:10.1016/j.jconrel.2015.07.017 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jconrel.2015.07.017 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0168365915300304 |
|---|
| | DOI: https://doi.org/10.1016/j.jconrel.2015.07.017 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Handheld gamma camera |
|---|
| | Maghemite |
|---|
| | Magnetic resonance imaging (MRI) |
|---|
| | rHSA nanoparticles |
|---|
| | Single photon emission computed tomography-computer tomography (SPECT-CT) |
|---|
| | t-PA-ligands to galectins |
|---|
| | t-PApeptide1 |
|---|
| K10plus-PPN: | 1713903555 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer / Rosenberger, Ina [VerfasserIn]; 17 July 2015 (Online-Ressource)
