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| Verfasst von: | Yamamoto, Akihisa [VerfasserIn]  |
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| | Abuillan, Wasim [VerfasserIn] |
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| | Burk, Alexandra Serena [VerfasserIn] |
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| | Körner, Alexander [VerfasserIn] |
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| | Ries, Annika [VerfasserIn] |
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| | Werz, Daniel B. [VerfasserIn] |
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| | Demé, Bruno [VerfasserIn] |
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| | Tanaka, Motomu [VerfasserIn] |
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| Titel: | Influence of length and conformation of saccharide head groups on the mechanics of glycolipid membranes |
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| Titelzusatz: | unraveled by off-specular neutron scattering |
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| Verf.angabe: | Akihisa Yamamoto, Wasim Abuillan, Alexandra S. Burk, Alexander Körner, Annika Ries, Daniel B. Werz, Bruno Demé and Motomu Tanaka |
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| E-Jahr: | 2015 |
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| Jahr: | 1 April 2015 |
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| Umfang: | ) S. |
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| Fussnoten: | Gesehen am 09.07.2020 |
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| Titel Quelle: | Enthalten in: The journal of chemical physics |
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| Ort Quelle: | Melville, NY : American Institute of Physics, 1933 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 142(2015,15) Artikel-Nummer 154907, 9 Seiten |
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| ISSN Quelle: | 1089-7690 |
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| Abstract: | The mechanical properties of multilayer stacks of Gb3 glycolipid that play key roles in metabolic disorders (Fabry disease) were determined quantitatively by using specular and off-specular neutron scattering. Because of the geometry of membrane stacks deposited on planar substrates, the scattered intensity profile was analyzed in a 2D reciprocal space map as a function of in-plane and out-of-plane scattering vector components. The two principal mechanical parameters of the membranes, namely, bending rigidity and compression modulus, can be quantified by full calculation of scattering functions with the aid of an effective cut-off radius that takes the finite sample size into consideration. The bulkier “bent” Gb3 trisaccharide group makes the membrane mechanics distinctly different from cylindrical disaccharide (lactose) head groups and shorter “bent” disaccharide (gentiobiose) head groups. The mechanical characterization of membranes enriched with complex glycolipids has high importance in understanding the mechanisms of diseases such as sphingolipidoses caused by the accumulation of non-degenerated glycosphingolipids in lysosomes or inhibition of protein synthesis triggered by the specific binding of Shiga toxin to Gb3. |
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| DOI: | doi:10.1063/1.4918585 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1063/1.4918585 |
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| | Volltext: https://aip.scitation.org/doi/10.1063/1.4918585 |
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| | DOI: https://doi.org/10.1063/1.4918585 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1724128930 |
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| Verknüpfungen: | → Zeitschrift |
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Influence of length and conformation of saccharide head groups on the mechanics of glycolipid membranes / Yamamoto, Akihisa [VerfasserIn]; 1 April 2015 (Online-Ressource)
