Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography

• Verfasst von: Golatta, Michael [VerfasserIn]
• Verfasst von: Baggs, Christina [VerfasserIn]
• Verfasst von: Schweitzer-Martin, Mirjam [VerfasserIn]
• Verfasst von: Domschke, Christoph [VerfasserIn]
• Verfasst von: Schott, Sarah [VerfasserIn]
• Verfasst von: Harcos, Aba [VerfasserIn]
• Verfasst von: Scharf, Alexander [VerfasserIn]
• Verfasst von: Junkermann, Hans [VerfasserIn]
• Verfasst von: Rauch, Geraldine [VerfasserIn]
• Verfasst von: Rom, Joachim [VerfasserIn]
• Verfasst von: Sohn, Christof [VerfasserIn]
• Verfasst von: Heil, Jörg [VerfasserIn]
• Titel: Evaluation of an automated breast 3D-ultrasound system by comparing it with hand-held ultrasound (HHUS) and mammography
• Verf.angabe: Michael Golatta, Christina Baggs, Mirjam Schweitzer-Martin, Christoph Domschke, Sarah Schott, Aba Harcos, Alexander Scharf, Hans Junkermann, Geraldine Rauch, Joachim Rom, Christof Sohn, Joerg Heil
• Jahr: 2015
• Umfang: 7 S.
• Fussnoten: Published online: 14 October 2014 ; Gesehen am 13.07.2020
• Titel Quelle: Enthalten in: Archives of gynecology and obstetrics
• Ort Quelle: Berlin : Springer, 1870
• Jahr Quelle: 2015
• Band/Heft Quelle: 291(2015), 4, Seite 889-895
• ISSN Quelle: 1432-0711
• DOI: doi:10.1007/s00404-014-3509-9
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1724485563

Abstract

Purpose: Automated three-dimensional (3D) breast ultrasound (US) systems are meant to overcome the shortcomings of hand-held ultrasound (HHUS). The aim of this study is to analyze and compare clinical performance of an automated 3D-US system by comparing it with HHUS, mammography and the clinical gold standard (defined as the combination of HHUS, mammography and—if indicated—histology). Methods: Nine hundred and eighty three patients (=1,966 breasts) were enrolled in this monocentric, explorative and prospective cohort study. All examinations were analyzed blinded to the patients´ history and to the results of the routine imaging. The agreement of automated 3D-US with HHUS, mammography and the gold standard was assessed with kappa statistics. Sensitivity, specificity and positive and negative predictive value were calculated to assess the test performance. Results: Blinded to the results of the gold standard the agreement between automated 3D-US and HHUS or mammography was fair, given by a Kappa coefficient of 0.31 (95 % CI [0.26;0.36], p\0.0001) and 0.25 (95 % CI [0.2;0.3], p\ 0.0001), respectively. Our results showed a high negative predictive value (NPV) of 98 %, a high specificity of 85 % and a sensitivity of 74 % based on the cases with US-guided biopsy. Including the cases where the lesion was seen in a second-look automated 3D-US the sensitivity improved to 84 % (NPV = 99 %, specificity = 85 %). Conclusion: The results of this study let us suggest, that automated 3D-US might be a helpful new tool in breast imaging, especially in screening.