Ultrastructure of the replication sites of positive-strand RNA viruses

• Verfasst von: Harak, Christian [VerfasserIn]
• Verfasst von: Lohmann, Volker [VerfasserIn]
• Titel: Ultrastructure of the replication sites of positive-strand RNA viruses
• Verf.angabe: Christian Harak, Volker Lohmann
• E-Jahr: 2015
• Jahr: 5 March 2015
• Umfang: 16 S.
• Fussnoten: Gesehen am 13.07.2020
• Titel Quelle: Enthalten in: Virology
• Ort Quelle: San Diego, Calif. [u.a.] : Elsevier, 1955
• Jahr Quelle: 2015
• Band/Heft Quelle: 479-480(2015), Seite 418-433
• ISSN Quelle: 1096-0341
• DOI: doi:10.1016/j.virol.2015.02.029
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Host factor
• Sach-SW: Membrane
• Sach-SW: Positive strand RNA virus
• Sach-SW: Replication factory
• Sach-SW: RNA replication
• Sach-SW: RNA synthesis
• K10plus-PPN: 1724506498

Abstract

Positive strand RNA viruses replicate in the cytoplasm of infected cells and induce intracellular membranous compartments harboring the sites of viral RNA synthesis. These replication factories are supposed to concentrate the components of the replicase and to shield replication intermediates from the host cell innate immune defense. Virus induced membrane alterations are often generated in coordination with host factors and can be grouped into different morphotypes. Recent advances in conventional and electron microscopy have contributed greatly to our understanding of their biogenesis, but still many questions remain how viral proteins capture membranes and subvert host factors for their need. In this review, we will discuss different representatives of positive strand RNA viruses and their ways of hijacking cellular membranes to establish replication complexes. We will further focus on host cell factors that are critically involved in formation of these membranes and how they contribute to viral replication.