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Verfasst von:Eckstein, Eugenia [VerfasserIn]   i
 Pyrski, Martina [VerfasserIn]   i
 Pinto, Silvia [VerfasserIn]   i
 Freichel, Marc [VerfasserIn]   i
 Vennekens, Rudi [VerfasserIn]   i
 Zufall, Frank [VerfasserIn]   i
Titel:Cyclic regulation of Trpm4 expression in female vomeronasal neurons driven by ovarian sex hormones
Verf.angabe:Eugenia Eckstein, Martina Pyrski, Silvia Pinto, Marc Freichel, Rudi Vennekens, Frank Zufall
E-Jahr:2020
Jahr:13 April 2020
Umfang:12$p105(2020) Artikel-Nummer 103495, 12 Seiten S.
Fussnoten:Gesehen am 13.07.2020
Titel Quelle:Enthalten in: Molecular and cellular neuroscience
Ort Quelle:San Diego, Calif. : Elsevier, 1990
Jahr Quelle:2020
Band/Heft Quelle:105(2020)
ISSN Quelle:1095-9327
Abstract:The vomeronasal organ (VNO), the sensory organ of the mammalian accessory olfactory system, mediates the activation of sexually dimorphic reproductive behavioral and endocrine responses in males and females. It is unclear how sexually dimorphic and state-dependent responses are generated by vomeronasal sensory neurons (VSNs). Here, we report the expression of the transient receptor potential (TRP) channel Trpm4, a Ca2+-activated monovalent cation channel, as a second TRP channel present in mouse VSNs, in addition to the diacylglycerol-sensitive Trpc2 channel. The expression of Trpm4 in the mouse VNO is sexually dimorphic and, in females, is tightly linked to their reproductive cycle. We show that Trpm4 protein expression is upregulated specifically during proestrus and estrus, when female mice are about to ovulate and become sexually active and receptive. The cyclic regulation of Trpm4 expression in female VSNs depends on ovarian sex hormones and is abolished by surgical removal of the ovaries (OVX). Trpm4 upregulation can be restored in OVX mice by systemic treatment with 17 beta-estradiol, requires endogenous activity of aromatase enzyme, and is strongly reduced during late pregnancy. This cyclic regulation of Trpm4 offers a neural mechanism by which female mice could regulate the relative strength of sensory signals in their VSNs, depending on hormonal state. Trpm4 is likely to participate in sex-specific, estrous cycle-dependent and sex hormone-regulated functions of the VNO, and may serve as a previously unknown genetic substrate for dissecting mammalian sexually dimorphic cellular and behavioral responses.
DOI:doi:10.1016/j.mcn.2020.103495
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.mcn.2020.103495
 DOI: https://doi.org/10.1016/j.mcn.2020.103495
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:activation
 Aromatase
 behaviors
 ca2+-activated cation channel
 Exemestane
 mice
 neural-control
 odor
 Olfactory
 Pheromone sensing
 pheromones
 receptor
 responses
 system
 Trpm4-IRES-Cre
 Trpm5
K10plus-PPN:1724509349
Verknüpfungen:→ Zeitschrift

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