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| Verfasst von: | Linden, Fabian [VerfasserIn]  |
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| | Domschke, Gabriele [VerfasserIn] |
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| | Erbel, Christian [VerfasserIn] |
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| | Akhavanpoor, Mohammadreza [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Gleißner, Christian A. [VerfasserIn] |
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| Titel: | Inflammatory therapeutic targets in coronary atherosclerosis - from molecular biology to clinical application |
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| Verf.angabe: | Fabian Linden, Gabriele Domschke, Christian Erbel, Mohammadreza Akhavanpoor, Hugo A. Katus and Christian A. Gleissner |
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| E-Jahr: | 2014 |
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| Jahr: | 21 November 2014 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 14.07.2020 |
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| Titel Quelle: | Enthalten in: Frontiers in physiology |
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| Ort Quelle: | Lausanne : Frontiers Research Foundation, 2007 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 5(2014) Artikel-Nummer 455, 11 Seiten |
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| ISSN Quelle: | 1664-042X |
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| Abstract: | Atherosclerosis is the leading cause of death worldwide. Over the past two decades, it has been clearly recognized that atherosclerosis is an inflammatory disease of the arterial wall. Accumulating data from animal experiments have supported this hypothesis, however, clinical applications making use of this knowledge remain scarce. In spite of optimal interventional and medical therapy, the risk for recurrent myocardial infarction remains by about 20% over three years after acute coronary syndromes, novel therapies to prevent atherogenesis or treat atherosclerosis are urgently needed. This review summarizes selected potential molecu-lar inflammatory targets that may be of clinical relevance. We also review recent and ongoing clinical trails that target inflammatory processes aiming at preventing adverse cardiovascular events. Overall, it seems surprising that translation of basic science into clinical practice has not been a great success. In conclusion, we propose to focus on specific efforts that promote translational science in order to improve outcome and prognosis of patients suffering from atherosclerosis. |
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| DOI: | doi:10.3389/fphys.2014.00455 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3389/fphys.2014.00455 |
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| | Volltext: https://www.frontiersin.org/articles/10.3389/fphys.2014.00455/full |
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| | DOI: https://doi.org/10.3389/fphys.2014.00455 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Atherosclerosis |
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| | clinical trials |
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| | Coronary Artery Disease |
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| | Inflammation |
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| | prevention |
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| K10plus-PPN: | 1724622765 |
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| Verknüpfungen: | → Zeitschrift |
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Inflammatory therapeutic targets in coronary atherosclerosis - from molecular biology to clinical application / Linden, Fabian [VerfasserIn]; 21 November 2014 (Online-Ressource)
