Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis

• Verfasst von: Keller, Andreas [VerfasserIn]
• Verfasst von: Haas, Jan [VerfasserIn]
• Verfasst von: Jarius, Sven [VerfasserIn]
• Verfasst von: Meder, Benjamin [VerfasserIn]
• Titel: Next-generation sequencing identifies altered whole blood microRNAs in neuromyelitis optica spectrum disorder which may permit discrimination from multiple sclerosis
• Verf.angabe: Andreas Keller, Petra Leidinger, Eckart Meese, Jan Haas, Christina Backes, Ludwig Rasche, Janina R. Behrens, Catherina Pfuhl, Katharina Wakonig, René M. Gieß, Sven Jarius, Benjamin Meder, Judith Bellmann-Strobl, Friedemann Paul, Florence C. Pache and Klemens Ruprecht
• E-Jahr: 2015
• Jahr: 31 October 2015
• Umfang: 12 S.
• Fussnoten: Gesehen am 17.07.2020
• Titel Quelle: Enthalten in: Journal of neuroinflammation
• Ort Quelle: London : BioMed Central, 2004
• Jahr Quelle: 2015
• Band/Heft Quelle: 12(2015) Artikel-Nummer 196, 12 Seiten
• ISSN Quelle: 1742-2094
• DOI: doi:10.1186/s12974-015-0418-1
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1724624865

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) have a similar clinical phenotype but represent distinct diseases, requiring different therapies. MicroRNAs (miRNAs) are short non-coding RNAs whose expression profiles can serve as diagnostic biomarkers and which may be involved in the pathophysiology of neuroinflammatory diseases. Here, we analyzed miRNA profiles in serum and whole blood of patients with NMOSD and clinically isolated syndrome (CIS)/relapsing-remitting MS (RRMS) as well as healthy controls by next-generation sequencing (NGS).