| |  Online-Ressource |
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| Verfasst von: | Shen, Ying [VerfasserIn]  |
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| | Wang, Xiaohong [VerfasserIn] |
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| | Lu, Junyan [VerfasserIn] |
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| | Salfenmoser, Martin [VerfasserIn] |
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| | Wirsik, Naita Maren [VerfasserIn] |
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| | Schleußner, Nikolai [VerfasserIn] |
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| | Imle, Andrea [VerfasserIn] |
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| | Freire Valls, Aida [VerfasserIn] |
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| | Radhakrishnan, Praveen [VerfasserIn] |
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| | Liang, Jie [VerfasserIn] |
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| | Wang, Guoliang [VerfasserIn] |
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| | Muley, Thomas [VerfasserIn] |
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| | Schneider, Martin [VerfasserIn] |
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| | Ruiz de Almodóvar, Carmen [VerfasserIn] |
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| | Diz Muñoz, Alba [VerfasserIn] |
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| | Schmidt, Thomas [VerfasserIn] |
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| Titel: | Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer |
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| Verf.angabe: | Ying Shen, Xiaohong Wang, Junyan Lu, Martin Salfenmoser, Naita Maren Wirsik, Nikolai Schleussner, Andrea Imle, Aida Freire Valls, Praveen Radhakrishnan, Jie Liang, Guoliang Wang, Thomas Muley, Martin Schneider, Carmen Ruiz de Almodovar, Alba Diz-Muñoz, and Thomas Schmidt |
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| E-Jahr: | 2020 |
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| Jahr: | June 8, 2020 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 14.07.2020 |
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| Titel Quelle: | Enthalten in: Cancer cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2002 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 37(2020), 6, Seite 800-817 |
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| ISSN Quelle: | 1878-3686 |
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| Abstract: | Tumors are influenced by the mechanical properties of their microenvironment. Using patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver metastases than in primary colorectal tumors. Highly activated metastasis-associated fibroblasts increase tissue stiffness, which enhances angiogenesis and anti-angiogenic therapy resistance. Drugs targeting the renin-angiotensin system, normally prescribed to treat hypertension, inhibit fibroblast contraction and extracellular matrix deposition, thereby reducing liver metastases stiffening and increasing the anti-angiogenic effects of bevacizumab. Patients treated with bevacizumab showed prolonged survival when concomitantly treated with renin-angiotensin inhibitors, highlighting the importance of modulating the mechanical microenvironment for therapeutic regimens. |
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| DOI: | doi:10.1016/j.ccell.2020.05.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.ccell.2020.05.005 |
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| | DOI: https://doi.org/10.1016/j.ccell.2020.05.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | activation protein |
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| | carcinoma-associated fibroblasts |
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| | extracellular-matrix |
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| | fibrotic focus |
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| | focal adhesion maturation |
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| | lysyl oxidase |
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| | renin-angiotensin system |
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| | stress |
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| | tissue growth-factor |
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| | tumor vasculature |
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| K10plus-PPN: | 1724725807 |
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| Verknüpfungen: | → Zeitschrift |
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Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer / Shen, Ying [VerfasserIn]; June 8, 2020 (Online-Ressource)
