An IT architecture for systems medicine

• Verfasst von: Ganzinger, Matthias [VerfasserIn]
• Verfasst von: Gietzelt, Matthias [VerfasserIn]
• Verfasst von: Karmen, Christian [VerfasserIn]
• Verfasst von: Firnkorn, Daniel [VerfasserIn]
• Verfasst von: Knaup-Gregori, Petra [VerfasserIn]
• Titel: An IT architecture for systems medicine
• Verf.angabe: Matthias Ganzinger, Matthias Gietzelt, Christian Karmen, Daniel Firnkorn, and Petra Knaup
• Jahr: 2015
• Umfang: 5 S.
• Fussnoten: Gesehen am15.07.2020
• Titel Quelle: Enthalten in: Medical Informatics Europe Conference (26. : 2015 : Madrid)Digital healthcare empowering Europeans
• Ort Quelle: Amsterdam : IOS Press, 2015
• Jahr Quelle: 2015
• Band/Heft Quelle: 210(2015), Seite 185-189
• ISBN Quelle: 978-1-61499-512-8
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Decision Support Systems, Clinical
• Sach-SW: Electronic Health Records
• Sach-SW: Meaningful Use
• Sach-SW: Medical Record Linkage
• Sach-SW: Systems Analysis
• Sach-SW: Systems Integration
• Sach-SW: User-Computer Interface
• K10plus-PPN: 1724800507

Abstract

Systems medicine aims to support treatment of complex diseases like cancer by integrating all available data for the disease. To provide such a decision support in clinical practice, a suitable IT architecture is necessary. We suggest a generic architecture comprised of the following three layers: data representation, decision support, and user interface. For the systems medicine research project "Clinically-applicable, omics-based assessment of survival, side effects, and targets in multiple myeloma" (CLIOMMICS) we developed a concrete instance of the generic architecture. We use i2b2 for representing the harmonized data. Since no deterministic model exists for multiple myeloma we use case-based reasoning for decision support. For clinical practice, visualizations of the results must be intuitive and clear. At the same time, they must communicate the uncertainty immanent in stochastic processes. Thus, we develop a specific user interface for systems medicine based on the web portal software Liferay.