| |  Online-Ressource |
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| Verfasst von: | Saum, Kai-Uwe [VerfasserIn]  |
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| | Dieffenbach, Aida Karina [VerfasserIn] |
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| | Müezzinler, Aysel [VerfasserIn] |
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| | Müller, Heiko [VerfasserIn] |
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| | Holleczek, Bernd [VerfasserIn] |
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| | Stegmaier, Christa [VerfasserIn] |
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| | Butterbach, Katja [VerfasserIn] |
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| | Schick, Matthias [VerfasserIn] |
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| | Canzian, Federico [VerfasserIn] |
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| | Stammer, Hermann [VerfasserIn] |
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| | Boukamp, Petra [VerfasserIn] |
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| | Hauer, Klaus [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | Frailty and telomere length |
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| Titelzusatz: | cross-sectional analysis in 3537 older adults from the ESTHER cohort |
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| Verf.angabe: | Kai-Uwe Saum, Aida Karina Dieffenbach, Aysel Müezzinler, Heiko Müller, Bernd Holleczek, Christa Stegmaier, Katja Butterbach, Matthias Schick, Federico Canzian, Hermann Stammer, Petra Boukamp, Klaus Hauer, Hermann Brenner |
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| E-Jahr: | 2014 |
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| Jahr: | 21 August 2014 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 15.07.2020 |
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| Titel Quelle: | Enthalten in: Experimental gerontology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1964 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 58(2014), Seite 250-255 |
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| ISSN Quelle: | 1873-6815 |
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| Abstract: | Both telomere length and frailty were observed to be associated with aging. Whether and to what extent telomere length is related to frailty is essentially unknown. In this cross-sectional analysis of baseline data of 3537 community-dwelling adults aged 50 to 75years of a large German cohort study, we assessed the hypothesis that shorter telomere length might be a biological marker for frailty. Using whole blood DNA we examined mean telomere repeat copy to single gene copy number (T/S ratio) using quantitative PCR. Construction of a frailty index (FI) was based on a deficit accumulation approach, which quantifies frailty as ratio of the deficits present divided by the total number of deficits considered. Mean FI was determined according to age by tertiles of T/S ratio. Furthermore, we used correlation analyses stratified for gender and age groups to examine the association of the T/S ratio with frailty. Mean FI value was similar across tertiles of the T/S ratio (0.24±0.14, 0.24±0.14 and 0.23±0.14, respectively (p=0.09)), and FI and the T/S ratio were uncorrelated in gender- and age-specific analyses. In conclusion, T/S ratio and frailty were unrelated in this large sample of older adults. T/S ratio may therefore not be a meaningful biological marker for frailty. |
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| DOI: | doi:10.1016/j.exger.2014.08.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.exger.2014.08.009 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0531556514002459 |
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| | DOI: https://doi.org/10.1016/j.exger.2014.08.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Elderly |
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| | Frailty |
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| | Frailty index |
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| | Telomere length |
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| | Telomeres |
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| K10plus-PPN: | 1724831585 |
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| Verknüpfungen: | → Zeitschrift |
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Frailty and telomere length / Saum, Kai-Uwe [VerfasserIn]; 21 August 2014 (Online-Ressource)
