Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT

• Verfasst von: Bazarbachi, Ali [VerfasserIn]
• Verfasst von: Cwynarski, K. [VerfasserIn]
• Verfasst von: Boumendil, A. [VerfasserIn]
• Verfasst von: Finel, H. [VerfasserIn]
• Verfasst von: Fields, P. [VerfasserIn]
• Verfasst von: Raj, K. [VerfasserIn]
• Verfasst von: Nagler, A. [VerfasserIn]
• Verfasst von: Mohty, M. [VerfasserIn]
• Verfasst von: Sureda, A. [VerfasserIn]
• Verfasst von: Dreger, Peter [VerfasserIn]
• Verfasst von: Hermine, O. [VerfasserIn]
• Titel: Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT
• Titelzusatz: a retrospective study by the EBMT LWP
• Verf.angabe: A. Bazarbachi, K. Cwynarski, A. Boumendil, H. Finel, P. Fields, K. Raj, A. Nagler, M. Mohty, A. Sureda, P. Dreger and O. Hermine
• E-Jahr: 2014
• Jahr: 14 July 2014
• Umfang: 3 S.
• Fussnoten: Gesehen am 17.07.2020
• Titel Quelle: Enthalten in: Bone marrow transplantation
• Ort Quelle: London : Springer Nature, 1997
• Jahr Quelle: 2014
• Band/Heft Quelle: 49(2014), 10, Seite 1266-1268
• ISSN Quelle: 1476-5365
• DOI: doi:10.1038/bmt.2014.143
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 172508838X

Abstract

Adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis. Experience with allo-SCT for ATL appears encouraging but is limited to Japanese series. This retrospective analysis of the EBMT registry revealed 21 HTLV-I seropositive ATL including 7 acute and 12 lymphoma subtypes. Four patients received auto-SCT and rapidly died from ATL. Out of 17 allo-SCT (4 myeloablative, 13 reduced intensity), 6 are still alive (4 were in CR1 at SCT). Eleven patients died within 2 years, eight from relapse/progression and three from transplant toxicity. Six of seven informative patients who lived >12 months had chronic GVHD. Overall these results indicate that allo-SCT but not auto-SCT may salvage a subset of ATL patients, supporting the existence of graft vs ATL effect also in non-Japanese patients.