| |  Online-Ressource |
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| Verfasst von: | Osman, Noha [VerfasserIn]  |
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| | Mahmoud, Amr H. [VerfasserIn] |
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| | Klein, Christian D. [VerfasserIn] |
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| | Allarà, Marco [VerfasserIn] |
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| | Marzo, Vincenzo Di [VerfasserIn] |
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| | Abouzid, Khaled M. [VerfasserIn] |
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| | Abadi, Ashraf H. [VerfasserIn] |
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| Titel: | Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB2-selective ligands |
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| Verf.angabe: | Noha A. Osman, Amr H. Mahmoud, Christian D. Klein, Marco Allarà, Vincenzo Di Marzo, Khaled M. Abouzid and Ashraf H. Abadi |
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| E-Jahr: | 2014 |
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| Jahr: | 31 July 2014 |
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| Umfang: | 6 S. |
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| Teil: | volume:5 |
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| | year:2014 |
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| | number:10 |
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| | pages:1571-1576 |
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| | extent:6 |
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| Fussnoten: | Im Titel ist "2" in CB2 tiefgestellt ; Gesehen am 20.07.2020 |
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| Titel Quelle: | Enthalten in: MedChemComm |
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| Ort Quelle: | Cambridge : RSC Publ., 2010 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 5(2014), 10, Seite 1571-1576 |
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| ISSN Quelle: | 2040-2511 |
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| Abstract: | Herein, we report the synthesis of naphthalene, dihydrobenzodioxine and fluorene derivatives with extended side chains and their biological evaluation as ligands of CB1 and CB2 receptors. Compounds 6a and 18b showed Ki values in the submicromolar range and relatively high selectivity toward CB2. Active compounds represent new scaffolds with such type of activity. Moreover, a multiple XED-based field templates model has been constructed for the activity interpretation of some of the synthesised compounds. The reported ligands can serve as a template to develop new CB2 ligands with enhanced potency and selectivity, and the computational model can be applied for SAR interpretation and/or structure optimization of any other CB2-selective ligand(s). |
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| DOI: | doi:10.1039/C4MD00232F |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1039/C4MD00232F |
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| | Volltext: https://pubs.rsc.org/en/content/articlelanding/2014/md/c4md00232f |
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| | DOI: https://doi.org/10.1039/C4MD00232F |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1725162849 |
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| Verknüpfungen: | → Zeitschrift |
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Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB2-selective ligands / Osman, Noha [VerfasserIn]; 31 July 2014 (Online-Ressource)
