| |  Online-Ressource |
|---|
| Verfasst von: | Yu, Tao [VerfasserIn]  |
|---|
| | Jia, Tianye [VerfasserIn] |
|---|
| | Zhu, Liping [VerfasserIn] |
|---|
| | Desrivieres, Sylvane [VerfasserIn] |
|---|
| | Macare, Christine [VerfasserIn] |
|---|
| | Bi, Yan [VerfasserIn] |
|---|
| | Bokde, Arun L. W. [VerfasserIn] |
|---|
| | Quinlan, Erin Burke [VerfasserIn] |
|---|
| | Heinz, Andreas [VerfasserIn] |
|---|
| | Ittermann, Bernd [VerfasserIn] |
|---|
| | Liu, ChuanXin [VerfasserIn] |
|---|
| | Ji, Lei [VerfasserIn] |
|---|
| | Banaschewski, Tobias [VerfasserIn] |
|---|
| | Ren, Decheng [VerfasserIn] |
|---|
| | Du, Li [VerfasserIn] |
|---|
| | Hou, Binyin [VerfasserIn] |
|---|
| | Flor, Herta [VerfasserIn] |
|---|
| | Frouin, Vincent [VerfasserIn] |
|---|
| | Garavan, Hugh [VerfasserIn] |
|---|
| | Gowland, Penny [VerfasserIn] |
|---|
| | Martinot, Jean-Luc [VerfasserIn] |
|---|
| | Martinot, Marie-Laure Paillere [VerfasserIn] |
|---|
| | Nees, Frauke [VerfasserIn] |
|---|
| | Orfanos, Dimitri Papadopoulos [VerfasserIn] |
|---|
| | Luo, Qiang [VerfasserIn] |
|---|
| | Chu, Congying [VerfasserIn] |
|---|
| | Paus, Tomas [VerfasserIn] |
|---|
| | Poustka, Luise [VerfasserIn] |
|---|
| | Hohmann, Sarah [VerfasserIn] |
|---|
| | Millenet, Sabina [VerfasserIn] |
|---|
| | Smolka, Michael N. [VerfasserIn] |
|---|
| | Vetter, Nora C. [VerfasserIn] |
|---|
| | Mennigen, Eva [VerfasserIn] |
|---|
| | Lei, Cai [VerfasserIn] |
|---|
| | Walter, Henrik [VerfasserIn] |
|---|
| | Fröhner, Juliane H. [VerfasserIn] |
|---|
| | Whelan, Robert [VerfasserIn] |
|---|
| | He, Guang [VerfasserIn] |
|---|
| | He, Lin [VerfasserIn] |
|---|
| | Schumann, Gunter [VerfasserIn] |
|---|
| | Robert, Gabriel [VerfasserIn] |
|---|
| Titel: | Cannabis-associated psychotic-like experiences are mediated by developmental changes in the parahippocampal gyrus |
|---|
| Verf.angabe: | Tao Yu, Tianye Jia, Liping Zhu, Sylvane Desrivieres, Christine Macare, Yan Bi, Arun L. W. Bokde, Erin Burke Quinlan, Andreas Heinz, Bernd Ittermann, ChuanXin Liu, Lei Ji, Tobias Banaschewski, Decheng Ren, Li Du, Binyin Hou, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Qiang Luo, Congying Chu, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Michael N. Smolka, Nora C. Vetter, Eva Mennigen, Cai Lei, Henrik Walter, Juliane H. Fröhner, Robert Whelan, Guang He, Lin He, Gunter Schumann, Gabriel Robert, the IMAGEN Consortium |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 20 March 2020 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Gesehen am 21.07.2020 |
|---|
| Titel Quelle: | Enthalten in: American Academy of Child and Adolescent PsychiatryJournal of the American Academy of Child and Adolescent Psychiatry |
|---|
| Ort Quelle: | Kidlington [u.a.] : Elsevier, 1987 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 59(2020), 5, Seite 642-649 |
|---|
| ISSN Quelle: | 1527-5418 |
|---|
| Abstract: | Objective: Cannabis consumption during adolescence has been reported as a risk factor for psychotic-like experiences (PLEs) and schizophrenia. However, brain developmental processes associated with cannabis-related PLEs are still poorly described. Method: A total of 706 adolescents from the general population who were recruited by the IMAGEN consortium had structural magnetic resonance imaging scans at both 14 and 19 years of age. We used deformation-based morphometry to map voxelwise brain changes between the two time points, using the pairwise algorithm in SPM12b. We used an a priori region-of-interest approach focusing on the hippocampus/parahippocampus to perform voxelwise linear regressions. Lifetime cannabis consumption was assessed using the European School Survey Project on Alcohol and other Drugs (ESPAD), and PLEs were assessed with the Comprehensive Assessment Psychotic-like experiences (CAPE) tool. We first tested whether hippocampus/parahippocampus development was associated with PLEs. Then we formulated and tested an a priori simple mediation model in which uncus development mediates the association between lifetime cannabis consumption and PLEs. Results: We found that PLEs were associated with reduced expansion within a specific region of the right hippocampus/parahippocampus formation, the uncus (p = .002 at the cluster level, p = .018 at the peak level). The partial simple mediation model revealed a significant total effect from lifetime cannabis consumption to PLEs (b = 0.069, 95% CI = 0.04-0.1, p = 2 x 10(-16)), as well as a small yet significant, indirect effect of right uncus development (0.004; 95% CI = 0.0004-0.01, p = .026). Conclusion: We show here that the uncus development is involved in the cerebral basis of PLEs in a population-based sample of healthy adolescents. |
|---|
| DOI: | doi:10.1016/j.jaac.2019.05.034 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jaac.2019.05.034 |
|---|
| | DOI: https://doi.org/10.1016/j.jaac.2019.05.034 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | segmentation |
|---|
| | population |
|---|
| | people |
|---|
| | 1st-episode schizophrenia |
|---|
| | abnormalities |
|---|
| | cannabis |
|---|
| | community |
|---|
| | deformation-based morphometry |
|---|
| | individuals |
|---|
| | instrument |
|---|
| | paired designed MRI |
|---|
| | psychotic-like experiences (PLEs) |
|---|
| | symptoms |
|---|
| | ultra-high risk |
|---|
| | uncus |
|---|
| K10plus-PPN: | 1725201860 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Cannabis-associated psychotic-like experiences are mediated by developmental changes in the parahippocampal gyrus / Yu, Tao [VerfasserIn]; 20 March 2020 (Online-Ressource)
