Advances in endothelial shear stress proteomics

• Verfasst von: Firasat, Sabika [VerfasserIn]
• Verfasst von: Hecker, Markus [VerfasserIn]
• Verfasst von: Binder, Lutz [VerfasserIn]
• Verfasst von: Asif, Abdul R. [VerfasserIn]
• Titel: Advances in endothelial shear stress proteomics
• Verf.angabe: Sabika Firasat, Markus Hecker, Lutz Binder and Abdul R. Asif
• E-Jahr: 2014
• Jahr: 12 July 2014
• Umfang: 9 S.
• Fussnoten: Gesehen am 22.07.2020
• Titel Quelle: Enthalten in: Expert review of proteomics
• Ort Quelle: Abingdon : Taylor & Francis Group, 2004
• Jahr Quelle: 2014
• Band/Heft Quelle: 11(2014), 5, Seite 611-619
• ISSN Quelle: 1744-8387
• DOI: doi:10.1586/14789450.2014.933673
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: endothelial dysfunction
• Sach-SW: mass spectrometry
• Sach-SW: proteomics
• Sach-SW: shear stress
• K10plus-PPN: 1725261839

Abstract

The vascular endothelium lining the luminal surface of all blood vessels is constantly exposed to shear stress exerted by the flowing blood. Blood flow with high laminar shear stress confers protection by activation of antiatherogenic, antithrombotic and anti-inflammatory proteins, whereas low or oscillatory shear stress may promote endothelial dysfunction, thereby contributing to cardiovascular disease. Despite the usefulness of proteomic techniques in medical research, however, there are relatively few reports on proteome analysis of cultured vascular endothelial cells employing conditions that mimic in vivo shear stress attributes. This review focuses on the proteome studies that have utilized cultured endothelial cells to identify molecular mediators of shear stress and the roles they play in the regulation of endothelial function, and their ensuing effect on vascular function in general. It provides an overview on current strategies in shear stress-related proteomics and the key proteins mediating its effects which have been characterized so far.