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Verfasst von:Berriel Diaz, Mauricio [VerfasserIn]   i
 Herzig, Stephan [VerfasserIn]   i
 Vegiopoulos, Alexandros [VerfasserIn]   i
Titel:Thermogenic adipocytes
Titelzusatz:from cells to physiology and medicine
Verf.angabe:Mauricio Berriel Diaz, Stephan Herzig, Alexandros Vegiopoulos
E-Jahr:2014
Jahr:7 July 2014
Umfang:12 S.
Fussnoten:Gesehen am 22.07.2020
Titel Quelle:Enthalten in: Metabolism
Ort Quelle:Orlando, Fla. : Elsevier, 1964
Jahr Quelle:2014
Band/Heft Quelle:63(2014), 10, Seite 1238-1249
ISSN Quelle:1532-8600
Abstract:The identification of active brown fat in humans has evoked widespread interest in the biology of non-shivering thermogenesis among basic and clinical researchers. As a consequence we have experienced a plethora of contributions related to cellular and molecular processes in thermogenic adipocytes as well as their function in the organismal context and their relevance to human physiology. In this review we focus on the cellular basis of non-shivering thermogenesis, particularly in relation to human health and metabolic disease. We provide an overview of the cellular function and distribution of thermogenic adipocytes in mouse and humans, and how this can be affected by environmental factors, such as prolonged cold exposure. We elaborate on recent evidence and open questions on the distinction of classical brown versus beige/brite adipocytes. Further, the origin of thermogenic adipocytes as well as current models for the recruitment of beige/brite adipocytes is discussed with an emphasis on the role of progenitor cells. Focusing on humans, we describe the expanding evidence for the activity, function and physiological relevance of thermogenic adipocytes. Finally, as the potential of thermogenic adipocyte activation as a therapeutic approach for the treatment of obesity and associated metabolic diseases becomes evident, we highlight goals and challenges for current research on the road to clinical translation.
DOI:doi:10.1016/j.metabol.2014.07.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.metabol.2014.07.002
 Volltext: http://www.sciencedirect.com/science/article/pii/S0026049514001978
 DOI: https://doi.org/10.1016/j.metabol.2014.07.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adipogenesis
 Beige/brite adipocytes
 Brown adipose tissue
 Obesity
 Thermogenesis
K10plus-PPN:1725275074
Verknüpfungen:→ Zeitschrift

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