Serum vitamin D levels and hypogonadism in men

• Verfasst von: Lerchbaum, Elisabeth [VerfasserIn]
• Verfasst von: Pilz, S. [VerfasserIn]
• Verfasst von: Trummer, C. [VerfasserIn]
• Verfasst von: Rabe, Thomas [VerfasserIn]
• Verfasst von: Schenk, M. [VerfasserIn]
• Verfasst von: Heijboer, A. C. [VerfasserIn]
• Verfasst von: Obermayer‐Pietsch, B. [VerfasserIn]
• Titel: Serum vitamin D levels and hypogonadism in men
• Verf.angabe: E. Lerchbaum, S. Pilz, C. Trummer, T. Rabe, M. Schenk, A.C. Heijboer and B. Obermayer‐Pietsch
• E-Jahr: 2014
• Jahr: 16 July 2014
• Umfang: 7 S.
• Fussnoten: Gesehen am 23.07.2020
• Titel Quelle: Enthalten in: Andrology
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 2013
• Jahr Quelle: 2014
• Band/Heft Quelle: 2(2014), 5, Seite 748-754
• ISSN Quelle: 2047-2927
• DOI: doi:10.1111/j.2047-2927.2014.00247.x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: androgens
• Sach-SW: hypogonadism
• Sach-SW: sex hormones
• K10plus-PPN: 1725358042

Abstract

There is inconsistent evidence on a possible association of vitamin D and androgen levels in men. We therefore aim to investigate the association of 25-hydroxyvitamin D (25(OH)D) with androgen levels in a cohort of middle-aged men. This cross-sectional study included 225 men with a median (interquartile range) age of 35 (30-41) years. We measured 25(OH)D, total testosterone (TT) and SHBG concentrations. Hypogonadism was defined as TT <10.4 nmol/L. We found no significant correlation of 25(OH)D and androgen levels. Furthermore, androgen levels were not significantly different across 25(OH)D quintiles. The overall prevalence of hypogonadism was 21.5% and lowest in men within 25(OH)D quintile 4 (82-102 nmol/L). We found a significantly increased risk of hypogonadism in men within the highest 25(OH)D quintile (>102 nmol/L) compared to men in quintile 4 (reference) in crude (OR 5.10, 1.51-17.24, p = 0.009) as well as in multivariate adjusted analysis (OR 9.21, 2.27-37.35, p = 0.002). We found a trend towards increased risk of hypogonadism in men within the lowest 25(OH)D quintile (≤43.9 nmol/L). In conclusion, our data suggest that men with very high 25(OH)D levels (>102 nmol/L) might be at an increased risk of hypogonadism. Furthermore, we observed a trend towards increased risk of hypogonadism in men with very low vitamin D levels indicating a U-shaped association of vitamin D levels and hypogonadism. With respect to risk of male hypogonadism, our results suggest optimal serum 25(OH)D concentrations of 82-102 nmol/L.