Reference values for left and right ventricular trabeculation and non-compacted myocardium

• Verfasst von: André, Florian [VerfasserIn]
• Verfasst von: Burger, Astrid [VerfasserIn]
• Verfasst von: Loßnitzer, Dirk [VerfasserIn]
• Verfasst von: Buß, Sebastian Johannes [VerfasserIn]
• Verfasst von: Abdel-Aty, Hassan [VerfasserIn]
• Verfasst von: Giannitsis, Evangelos [VerfasserIn]
• Verfasst von: Steen, Henning [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Titel: Reference values for left and right ventricular trabeculation and non-compacted myocardium
• Verf.angabe: Florian André, Astrid Burger, Dirk Loßnitzer, Sebastian J. Buss, Hassan Abdel-Aty, Evangelos Gianntisis, Henning Steen, Hugo A. Katus
• E-Jahr: 2015
• Jahr: 4 March 2015
• Umfang: 8 S.
• Fussnoten: Der Name Gianntisis ist falsch geschrieben ; Gesehen am 23.07.2020
• Titel Quelle: Enthalten in: International journal of cardiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1981
• Jahr Quelle: 2015
• Band/Heft Quelle: 185(2015), Seite 240-247
• ISSN Quelle: 1874-1754
• DOI: doi:10.1016/j.ijcard.2015.03.065
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Age
• Sach-SW: Cardiovascular magnetic resonance
• Sach-SW: Gender
• Sach-SW: Physiology
• Sach-SW: Reference values
• Sach-SW: Trabeculation
• K10plus-PPN: 1725368714

Abstract

Background - Since the differentiation between physiological and pathological trabeculation is challenging, we assessed its distribution in a reference population of selected healthy volunteers. - Methods - We studied 117 subjects (58 males) stratified into age tertiles and by gender. Cardiovascular magnetic resonance images were acquired using a standard SSFP-sequence. Left and right ventricular (LV/RV) end-diastolic (EDV), end-systolic (ESV) and trabeculated volumes indexed to the body surface area as well as ejection fraction (EF) were quantified in short-axis views. The maximum non-compacted-to-compacted (NC/C) ratio was measured in long-axis views. - Results - The trabeculated volumes were significantly larger in men than in women and decreased with age. The correlation between both was moderate (r=0.46; p<0.001). LV trabeculated volume was positively associated with EDV and ESV (r=0.74; r=0.59; both p<0.001) and negatively with EF (r=−0.27; p<0.005). It was no independent predictor for EF. The maximum NC/C ratio was >2.3 in 46.2% and >2.5 in 37.6% of the subjects, which is regarded as abnormal in current literature. The fraction of subjects with a maximum NC/C ratio >2.3 and the mean maximum NC/C ratio differed significantly between gender but not between age groups. An increasing NC/C ratio was associated with a significant decrease in EF (r=−0.21; p<0.05). - Conclusion - A considerable amount of healthy volunteers fulfils the current diagnostic criteria of LV noncompaction with female subjects showing a higher fraction of false-positive results than males. LV trabeculated volume is more pronounced in young subjects and declines with age. The use of age- and gender-specific reference values as provided in this study may facilitate the delineation of physiological and pathological findings.