Prediction of pathological complete response in breast cancer patients during neoadjuvant chemotherapy

• Verfasst von: Maier, Anna [VerfasserIn]
• Verfasst von: Heil, Jörg [VerfasserIn]
• Verfasst von: Harcos, Aba [VerfasserIn]
• Verfasst von: Sinn, Peter [VerfasserIn]
• Verfasst von: Rauch, Geraldine [VerfasserIn]
• Verfasst von: Uhlmann, Lorenz [VerfasserIn]
• Verfasst von: Gomez, Christina [VerfasserIn]
• Verfasst von: Stieber, Anne [VerfasserIn]
• Verfasst von: Funk, Annika [VerfasserIn]
• Verfasst von: Barr, Richard G. [VerfasserIn]
• Verfasst von: Hennigs, André [VerfasserIn]
• Verfasst von: Riedel, Fabian [VerfasserIn]
• Verfasst von: Schäfgen, Benedikt [VerfasserIn]
• Verfasst von: Fastner, Sarah [VerfasserIn]
• Verfasst von: Marmé, Frederik [VerfasserIn]
• Verfasst von: Sohn, Christof [VerfasserIn]
• Verfasst von: Golatta, Michael [VerfasserIn]
• Titel: Prediction of pathological complete response in breast cancer patients during neoadjuvant chemotherapy
• Titelzusatz: is shear wave elastography a useful tool in clinical routine?
• Verf.angabe: Anna Marie Maier, Jörg Heil, Aba Harcos, Hans-Peter Sinn, Geraldine Rauch, Lorenz Uhlmann, Christina Gomez, Anne Stieber, Annika Funk, Richard G. Barr, André Hennigs, Fabian Riedel, Benedikt Schäfgen, Sarah Hug, Frederik Marmé, Christof Sohn, Michael Golatta
• E-Jahr: 2020
• Jahr: 1 May 2020
• Umfang: 10 S.
• Fussnoten: Gesehen am 23.07.2020
• Titel Quelle: Enthalten in: European journal of radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1990
• Jahr Quelle: 2020
• Band/Heft Quelle: 128(2020) Artikel-Nummer 109025, 10 Seiten
• ISSN Quelle: 1872-7727
• DOI: doi:10.1016/j.ejrad.2020.109025
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 2D shear wave imaging
• Sach-SW: Breast neoplasms
• Sach-SW: Elasticity imaging techniques
• Sach-SW: Neoadjuvant therapy
• K10plus-PPN: 1725392194

Abstract

Objective - To compare the validity of Shear Wave Elastography (SWE) for the preoperative assessment of pathological complete response (pCR) to standard clinical assessment in breast cancer patients undergoing neoadjuvant chemotherapy (NACT). - Materials and Methods - This prospective, consecutive clinical trial was conducted under routine clinical practice. Analysis included 134 patients. SWE served as index test, final pathology from surgical specimen as reference standard. PCR (ypT0) was defined as primary endpoint. Elasticity changes were compared for the pCR- vs. non-pCR group. To determine the validity of shear wave velocity (Vs), ROC analyses and diagnostic accuracy parameters were calculated and compared to the final standard clinical assessment by physical examination, mammography and B-mode ultrasound (ycT+vs. ycT0). - Results - Vs was significantly reduced in pCR and non-pCR groups during NACT (pCR: ΔVs(abs)=3.90m/s, p<0.001; non-pCR: ΔVs(abs)=3.10m/s, p<0.001). The pCR-group showed significant lower Vs for all control visits (t1,2,END: p<0.001). ROC analysis of Vs yielded moderate AUCs for the total population (t0: 0.613, t1: 0.745, t2: 0.685, tEND: 0.718). Compared to standard clinical assessment, Vs(tEND) (cut-off: ≤3.35m/s) was superior in sensitivity (79.6 % vs. 54.5 %), NPV (86.4 % vs. 77.5 %), FNR (20.4 % vs. 45.5 %), inferior in specificity (58.6 % vs. 77.5 %), PPV (46.3 % vs. 54.5 %), FPR (41.4 % vs. 22.5 %). - Conclusion - SWE measures significant differences in tumour elasticity changes in pCR vs. non-pCR cases. SWE shows improved sensitivity compared to standard clinical assessment, high NPV and low FNR, but failed in specificity in order to predict pCR under routine conditions.