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| Verfasst von: | Salmina, Kristine [VerfasserIn]  |
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| | Gerashchenko, Bogdan I. [VerfasserIn] |
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| | Hausmann, Michael [VerfasserIn] |
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| | Vainshelbaum, Ninel M. [VerfasserIn] |
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| | Zayakin, Pawel [VerfasserIn] |
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| | Erenpreiss, Juris [VerfasserIn] |
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| | Freivalds, Talivaldis [VerfasserIn] |
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| | Cragg, Mark S. [VerfasserIn] |
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| | Erenpreisa, Jekaterina [VerfasserIn] |
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| Titel: | When three isn’t a crowd |
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| Titelzusatz: | a digyny concept for treatment-resistant, near-triploid human cancers |
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| Verf.angabe: | Kristine Salmina, Bogdan I. Gerashchenko, Michael Hausmann, Ninel M. Vainshelbaum, Pawel Zayakin, Juris Erenpreiss, Talivaldis Freivalds, Mark S. Cragg and Jekaterina Erenpreisa |
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| E-Jahr: | 2019 |
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| Jahr: | 19 July 2019 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 23.07.2020 |
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| Titel Quelle: | Enthalten in: Genes |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 10(2019,7) Artikel-Nummer 551, 20 Seiten |
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| ISSN Quelle: | 2073-4425 |
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| Abstract: | Near-triploid human tumors are frequently resistant to radio/chemotherapy through mechanisms that are unclear. We recently reported a tight association of male tumor triploidy with XXY karyotypes based on a meta-analysis of 15 tumor cohorts extracted from the Mitelman database. Here we provide a conceptual framework of the digyny-like origin of this karyotype based on the germline features of malignant tumors and adaptive capacity of digyny, which supports survival in adverse conditions. Studying how the recombinatorial reproduction via diploidy can be executed in primary cancer samples and HeLa cells after DNA damage, we report the first evidence that diploid and triploid cell sub-populations constitutively coexist and inter-change genomes via endoreduplicated polyploid cells generated through genotoxic challenge. We show that irradiated triploid HeLa cells can enter tripolar mitosis producing three diploid sub-subnuclei by segregation and pairwise fusions of whole genomes. Considering the upregulation of meiotic genes in tumors, we propose that the reconstructed diploid sub-cells can initiate pseudo-meiosis producing two “gametes” (diploid “maternal” and haploid “paternal”) followed by digynic-like reconstitution of a triploid stemline that returns to mitotic cycling. This process ensures tumor survival and growth by (1) DNA repair and genetic variation, (2) protection against recessive lethal mutations using the third genome. |
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| DOI: | doi:10.3390/genes10070551 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/genes10070551 |
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| | Volltext: https://www.mdpi.com/2073-4425/10/7/551 |
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| | DOI: https://doi.org/10.3390/genes10070551 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chemoresistance |
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| | digyny |
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| | near-triploid cancer |
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| | pedogamy |
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| | polynuclear cancer cells |
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| | radioresistance |
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| | reprogramming |
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| | tripolar mitosis |
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| | tumor blastomeres |
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| K10plus-PPN: | 1725474581 |
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| Verknüpfungen: | → Zeitschrift |
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When three isn’t a crowd / Salmina, Kristine [VerfasserIn]; 19 July 2019 (Online-Ressource)
