Cell culture models for hepatitis E virus

• Verfasst von: Fu, Rebecca Menhua [VerfasserIn]
• Verfasst von: Decker, Charlotte Caroline [VerfasserIn]
• Verfasst von: Dao Thi, Viet Loan [VerfasserIn]
• Titel: Cell culture models for hepatitis E virus
• Verf.angabe: Rebecca Menhua Fu, Charlotte Caroline Decker and Viet Loan Dao Thi
• E-Jahr: 2019
• Jahr: 3 July 2019
• Umfang: 22 S.
• Fussnoten: Gesehen am 27.07.2020
• Titel Quelle: Enthalten in: Viruses
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2020
• Band/Heft Quelle: 11(2020,7) Artikel-Nummer 608, 22 Seiten
• ISSN Quelle: 1999-4915
• DOI: doi:10.3390/v11070608
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cell culture systems
• Sach-SW: hepatitis E virus
• Sach-SW: hepatocyte polarization
• Sach-SW: stem cells
• K10plus-PPN: 1725567644

Abstract

Despite a growing awareness, hepatitis E virus (HEV) remains understudied and investigations have been historically hampered by the absence of efficient cell culture systems. As a result, the pathogenesis of HEV infection and basic steps of the HEV life cycle are poorly understood. Major efforts have recently been made through the development of HEV infectious clones and cellular systems that significantly advanced HEV research. Here, we summarize these systems, discussing their advantages and disadvantages for HEV studies. We further capitalize on the need for HEV-permissive polarized cell models to better recapitulate the entire HEV life cycle and transmission.