Neuroinflammation after intracerebral hemorrhage

• Verfasst von: Mracskó, Eva [VerfasserIn]
• Verfasst von: Veltkamp, Roland [VerfasserIn]
• Titel: Neuroinflammation after intracerebral hemorrhage
• Verf.angabe: Eva Mracsko and Roland Veltkamp
• E-Jahr: 2014
• Jahr: 20 November 2014
• Fussnoten: Gesehen am 28.07.2020
• Titel Quelle: Enthalten in: Frontiers in cellular neuroscience
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2014
• Band/Heft Quelle: 8(2014) Artikelnummer 388, 13 Seiten
• ISSN Quelle: 1662-5102
• DOI: doi:10.3389/fncel.2014.00388
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adaptive Immunity
• Sach-SW: innate immunity
• Sach-SW: intracerebral haemorrhage
• Sach-SW: Neuroinflammation
• Sach-SW: Stroke
• K10plus-PPN: 1725647842

Abstract

Spontaneous intracerebral haemorrhage (ICH) is a particularly severe type of stroke for which no specific treatment has been established yet. Although preclinical models of ICH have substantial methodological limitations, important insight into the pathophysiology has been gained. Mounting evidence suggests an important contribution of inflammatory mechanisms to brain damage and potentially repair. Neuroinflammation evoked by intracerebral blood involves the activation of resident microglia, the infiltration of systemic immune cells and the production of cytokines, chemokines extracellular proteases and reactive oxygen species. Previous studies focused on innate immunity including microglia, monocytes and granulocytes. More recently, the role of adaptive immune cells has received increasing attention. Little is currently known about the interactions among different immune cell populations in the setting of ICH. Nevertheless, immunomodulatory strategies are already being explored in ICH. To improve the chances of translation from preclinical models to patients, a better characterization of the neuroinflammation in patients is desirable.