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Verfasst von:Brix, Klaudia [VerfasserIn]   i
 Szumska, Joanna [VerfasserIn]   i
Titel:Auto-regulation of the thyroid gland beyond classical pathways
Verf.angabe:Klaudia Brix, Joanna Szumska, Jonas Weber, Maria Qatato, Vaishnavi Venugopalan, Alaa Al-Hashimi, Maren Rehders
E-Jahr:2020
Jahr:19. Februar 2020
Umfang:9 S.
Fussnoten:Gesehen am 28.07.2020
Titel Quelle:Enthalten in: Experimental and clinical endocrinology & diabetes
Ort Quelle:Stuttgart [u.a.] : Thieme, 1983
Jahr Quelle:2020
Band/Heft Quelle:128(2020), 6/7, Seite 437-445
ISSN Quelle:1439-3646
Abstract:This mini-review asks how self-regulation of the thyroid gland is realized at the cellular and molecular levels by canonical and non-canonical means. Canonical pathways of thyroid regulation comprise thyroid stimulating hormone-triggered receptor signaling. As part of non-canonical regulation, we hypothesized an interplay between protease-mediated thyroglobulin processing and thyroid hormone release into the circulation by means of thyroid hormone transporters like Mct8. We proposed a sensing mechanism by different thyroid hormone transporters, present in specific subcellular locations of thyroid epithelial cells, selectively monitoring individual steps of thyroglobulin processing, and thus, the cellular thyroid hormone status. Indeed, we found that proteases and thyroid hormone transporters are functionally inter-connected, however, in a counter-intuitive manner fostering self-thyrotoxicity in particular in Mct8- and/or Mct10-deficient mice. Furthermore, the possible role of the G protein-coupled receptor Taar1 is discussed, because we detected Taar1 at cilia of the apical plasma membrane of thyrocytes in vitro and in situ. Eventually, through pheno-typing Taar1-deficient mice, we identified a co-regulatory role of Taar1 and the thyroid stimulating hormone receptors. Recently, we showed that inhibition of thyroglobulin-processing enzymes results in disappearance of cilia from the apical pole of thyrocytes, while Taar1 is re-located to the endoplasmic reticulum. This pathway features a connection between thyrotropin-stimulated secretion of proteases into the thyroid follicle lumen and substrate-mediated self-assisted control of initially peri-cellular thyroglobulin processing, before its reinternalization by endocytosis, followed by extensive endo-lysosomal liberation of thyroid hormones, which are then released from thyroid follicles by means of thyroid hormone transporters.
DOI:doi:10.1055/a-1080-2969
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1055/a-1080-2969
 Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-1080-2969
 DOI: https://doi.org/10.1055/a-1080-2969
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1725677024
Verknüpfungen:→ Zeitschrift

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