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Verfasst von:Emmerich, Julian [VerfasserIn]   i
 Bachert, Peter [VerfasserIn]   i
 Ladd, Mark E. [VerfasserIn]   i
 Straub, Sina [VerfasserIn]   i
Titel:On the influence of two coexisting species of susceptibility-producing structures on the R2∗ relaxation rate
Verf.angabe:Julian Emmerich, Peter Bachert, Mark E. Ladd, Sina Straub
E-Jahr:2020
Jahr:September 1, 2020
Umfang:8 S.
Fussnoten:Gesehen am 30.07.2020
Titel Quelle:Enthalten in: Magnetic resonance imaging
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1982
Jahr Quelle:2020
Band/Heft Quelle:71(2020), Seite 170-177
ISSN Quelle:1873-5894
Abstract:Purpose - Tissue microstructure can influence quantitative magnetic resonance imaging such as relaxation rate measurements. Consequently, relaxation rate mapping can provide useful information on tissue microstructure. In this work, the theory on relaxation mechanisms of the change of the relaxation rate ∆R2⁎ in the presence of spherical susceptibility sources in a spin bearing medium is validated in simulations and phantom experiments for the coexistence of two species of susceptibility sources. - Methods - The influence of coexisting spherical perturbers with magnetic susceptibilitys of different signs was evaluated in Monte Carlo simulations including diffusion effects in the surrounding medium. Simulations were compared with relaxometry measurements at 1.5 Tesla and at 3 Tesla. The phantoms used to validate the simulations were built from agarose gel containing calcium carbonate and tungsten carbide particles of different size and concentration. - Results - The Monte Carlo simulations showed, that the change in relaxation rate only depends on the overall amount of susceptibility producing structures in the simulation volume and no difference was found, if mixtures of positive and negative particles were simulated. Phantom measurements within the static dephasing regime showed linear additivity of the effects from positive and negative susceptibility sources that were present within the same voxel. - Conclusions - In summary, both the simulations and the phantom measurements showed that changes in the relaxation rate ΔR2⁎ add up linearly for spherical particles with different susceptibilities within the same voxel if the conditions for the static dephasing regime are fulfilled. If particles with different susceptibilities have both different sizes and violate the conditions of the static dephasing regime, effects on relaxation rates might no longer be linear.
DOI:doi:10.1016/j.mri.2020.06.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.mri.2020.06.006
 Volltext: http://www.sciencedirect.com/science/article/pii/S0730725X20300680
 DOI: https://doi.org/10.1016/j.mri.2020.06.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Magnetic susceptibility
 Microstructure
 Relaxation rate
 Relaxation time
 Static dephasing regime
K10plus-PPN:1725958821
Verknüpfungen:→ Zeitschrift

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