| |  Online-Ressource |
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| Verfasst von: | Sambataro, Fabio [VerfasserIn]  |
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| | Fritze, Stefan [VerfasserIn] |
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| | Rashidi, Mahmoud [VerfasserIn] |
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| | Topor, Cristina E. [VerfasserIn] |
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| | Kubera, Katharina Maria [VerfasserIn] |
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| | Wolf, Robert Christian [VerfasserIn] |
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| | Hirjak, Dusan [VerfasserIn] |
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| Titel: | Moving forward |
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| Titelzusatz: | distinct sensorimotor abnormalities predict clinical outcome after 6 months in patients with schizophrenia |
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| Verf.angabe: | Fabio Sambataro, Stefan Fritze, Mahmoud Rashidi, Cristina E. Topor, Katharina M. Kubera, Robert C. Wolf, Dusan Hirjak |
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| E-Jahr: | 2020 |
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| Jahr: | 7 June 2020 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 04.08.2020 |
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| Titel Quelle: | Enthalten in: European neuropsychopharmacology |
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| Ort Quelle: | Amsterdam : Elsevier, 1990 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 36(2020), Seite 72-82 |
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| ISSN Quelle: | 1873-7862 |
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| Abstract: | Despite substantial efforts in the last decades, objective measures that can predict clinical outcome in patients with schizophrenia (SZ) after an acute psychotic episode are still lacking. Here, we introduced a comprehensive assessment of sensorimotor function to predict mid-term clinical outcome following an acute psychotic episode. This naturalistic follow-up of 43 patients with DSM-IV-TR diagnosis of SZ examined sensorimotor abnormalities (i.e. Neurological Soft Signs (NSS), parkinsonism, akathisia, catatonia and acute dyskinesia), psychopathology, cognition and psychosocial functioning using well-established instruments. A collection of statistical methods was used to examine the relationship between sensorimotor domain, psychopathology, cognition and psychosocial functioning. We also tested the clinical feasibility of this relationship when predicting clinical outcome after an acute psychotic episode. Longitudinal data were collected on 43 individuals after a follow-up period of >6 months. At follow-up, patients showed significantly reduced general symptom severity, as well as decreased levels of NSS, parkinsonism and catatonia. Further, NSS scores at baseline predicted PANSS negative scores and cognitive functioning at baseline. Finally, NSS scores at baseline predicted symptom change (reduction of PANSS positive and negative scores) at follow-up. In conclusion, our results suggest that NSS are significant predictors of poor clinical outcome in SZ at baseline and >6 months after an acute psychotic episode. These findings propose sensorimotor domain as state biomarker of SZ and support its predictive power with respect to treatment outcome. |
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| DOI: | doi:10.1016/j.euroneuro.2020.05.002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.euroneuro.2020.05.002 |
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| | DOI: https://doi.org/10.1016/j.euroneuro.2020.05.002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Catatonia |
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| | Longitudinal |
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| | NSS |
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| | Outcome |
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| | Schizophrenia |
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| | Sensorimotor abnormalities |
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| K10plus-PPN: | 1726150720 |
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| Verknüpfungen: | → Zeitschrift |
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