Physical activity and long-term quality of life among colorectal cancer survivors

• Verfasst von: Eyl, Ruth Elisa [VerfasserIn]
• Verfasst von: Koch, Lena [VerfasserIn]
• Verfasst von: Jansen, Lina [VerfasserIn]
• Verfasst von: Walter, Viola [VerfasserIn]
• Verfasst von: Carr, Prudence R. [VerfasserIn]
• Verfasst von: Hoffmeister, Michael [VerfasserIn]
• Verfasst von: Chang-Claude, Jenny [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Arndt, Volker [VerfasserIn]
• Titel: Physical activity and long-term quality of life among colorectal cancer survivors
• Titelzusatz: a population-based prospective study
• Verf.angabe: Ruth Elisa Eyl, Lena Koch-Gallenkamp, Lina Jansen, Viola Walter, Prudence R. Carr, Michael Hoffmeister, Jenny Chang-Claude, Hermann Brenner, Volker Arndt
• E-Jahr: 2020
• Jahr: April 6, 2020
• Umfang: 12 S.
• Fussnoten: Gesehen am 05.08.2020
• Titel Quelle: Enthalten in: Cancer Prevention Research
• Ort Quelle: Philadelphia, Pa. : AACR, 2008
• Jahr Quelle: 2020
• Band/Heft Quelle: 13(2020), 7, Seite 611-622
• ISSN Quelle: 1940-6215
• DOI: doi:10.1158/1940-6207.CAPR-19-0377
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1726243966

Abstract

Evidence suggests that physical activity(PA) is positively associated with health-related quality of life(QOL) in colorectal cancer(CRC) survivors. However, little is known regarding long-term effects of PA on QOL and if pre-diagnosis PA is associated with QOL in the years after diagnosis. Our study aimed to investigate the association of pre- and post-diagnosis PA with long-term QOL in CRC survivors. This study is based on a population-based cohort from Germany of 1781 newly diagnosed CRC survivors over a five-year period. Physical activity was assessed at diagnosis and at five-year follow up(5YFU). Quality of life was assessed by the EORTC Quality of Life Questionnaire-Core 30 at 5YFU. Multivariable linear regression was used to explore associations between pre- and post-diagnosis PA and QOL. No evidence of a positive association between higher levels of pre-diagnosis PA and better long-term QOL was found. Higher levels of pre-diagnosis work-related PA and vigorous PA were even associated with decreased QOL in domains such as cognitive (Beta(ß)= -2.52, 95% confidence interval(CI)=−3.77,-1.27; ß=-1.92, CI=-3.17,-0.67) and emotional functioning (ß=-2.52, CI=−3.84,-1.19; ß=-2.12, CI=-3.44,-0.80). In cross-sectional analyses, higher post-diagnosis PA was strongly associated with higher QOL. Survivors physically active at both pre- and post-diagnosis as well as survivors who increased their PA between pre- and post-diagnosis reported significantly higher long-term QOL compared to survivors who remained inactive at pre- and post-diagnosis. In this study, higher pre-diagnosis PA does not appear to be associated with higher QOL among long-term CRC survivors but our results support the importance of ongoing PA throughout survivorship.