Online-Ressource | |
Verfasst von: | Müller, Beat P. [VerfasserIn] |
Billeter, Adrian [VerfasserIn] | |
Fleming, Thomas [VerfasserIn] | |
Fischer, Lars [VerfasserIn] | |
Büchler, Markus W. [VerfasserIn] | |
Nawroth, Peter Paul [VerfasserIn] | |
Titel: | Nitrosative stress but not glycemic parameters correlate with improved neuropathy in nonseverely obese diabetic patients after Roux-Y gastric bypass |
Verf.angabe: | Beat P. Müller-Stich, Adrian T. Billeter, Thomas Fleming, Lars Fischer, Markus W. Büchler, Peter P. Nawroth |
Jahr: | 2015 |
Jahr des Originals: | 2014 |
Umfang: | 8 S. |
Fussnoten: | Available online 16 December 2014 ; Gesehen am 05.08.2020 |
Titel Quelle: | Enthalten in: Surgery for obesity and related diseases |
Ort Quelle: | New York, NY [u.a.] : Elsevier, 2005 |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 11(2015), 4, Seite 847-854 |
ISSN Quelle: | 1878-7533 |
Abstract: | Background - Diabetic neuropathy is common in type 2 diabetic patients (T2DM) but tight glycemic control does not improve the symptoms. In contrast, Roux-Y gastric bypass (RYGB) has a positive effect on active neuropathic symptoms, independent from glycemic control. The purpose of the present study was to identify potential mechanisms of improved diabetic neuropathic symptoms after RYGB. - Methods - A prospective cohort of 20 patients with insulin-dependent T2DM and BMI<35 kg/m2 were treated with RYGB. Nineteen patients had complete follow-up. Fasting glucose, HbA1c (glycated hemoglobin), markers for nitrosative, carbonyl, and oxidative stress (nitrotyrosine, carboxylated-lysine (CML), methylglyoxal, oxidized low-density-lipoprotein (oxLDL)) as well as Neuropeptid Y and Neurokinin A were investigated over 12 months. Neuropathy was assessed using the Neuropathy Deficit Score (NDS). - Results - The preoperative NDS improved within twelve months (5.1±0.6 to 2.6±0.4, P = .010). Fasting glucose and HbA1c also improved compared to preoperative values (201.1±16.6 mg/dL to 128±8.7 mg/dL, P = .004 and 8.5±0.3% (53±3.3 mmol/mol) to 7±0.3% (67±3.3 mmol/mol), P = .001, respectively). Nitrotyrosine, CML, and methylglyoxal all 3 decreased postoperatively (1067.3±266.9 nM to 355.8±36.4 nM, P = .003; 257.1±10.2 ng/ml to 215.3±18.3 ng/ml, P = .039; 402.3±3.9 nM to 163.4±10.3 nM, P = .002). OxLDL remained unchanged. Fasting glucose and HbA1c did not correlate with improved neuropathy. The decrease in nitrotyrosine correlated with improvement in the NDS after 6 and twelve months (r = .9, P<.001 and r = .68, P = .03). The decrease in methylglyoxal after 6 months correlated with decrease in NDS after twelve months (r = 0.897, P = .003). - Conclusion - RYGB seems to improve oxidative, nitrosative and carbonyl stress, known to have a causal role in diabetic neuropathy. |
DOI: | doi:10.1016/j.soard.2014.12.007 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.1016/j.soard.2014.12.007 |
Volltext: http://www.sciencedirect.com/science/article/pii/S1550728914004894 | |
DOI: https://doi.org/10.1016/j.soard.2014.12.007 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Carbonyl stress |
Diabetes | |
Gastric bypass | |
Metabolic surgery | |
Neuropathy | |
Oxidative stress | |
RYGB | |
K10plus-PPN: | 1726263010 |
Verknüpfungen: | → Zeitschrift |