A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells

• Verfasst von: Cheng, Xinlai [VerfasserIn]
• Verfasst von: Holenya, Pavlo [VerfasserIn]
• Verfasst von: Can, Suzan [VerfasserIn]
• Verfasst von: Alborzinia, Hamed [VerfasserIn]
• Verfasst von: Rubbiani, Riccardo [VerfasserIn]
• Verfasst von: Ott, Ingo [VerfasserIn]
• Verfasst von: Wölfl, Stefan [VerfasserIn]
• Titel: A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells
• Verf.angabe: Xinlai Cheng, Pavlo Holenya, Suzan Can, Hamed Alborzinia, Riccardo Rubbiani, Ingo Ott and Stefan Wölfl
• E-Jahr: 2014
• Jahr: [2014]
• Umfang: 15 S.
• Illustrationen: Illustrationen
• Fussnoten: Autor Pavlo Holenya falsch als "Palvo Holenya" angegeben ; Gesehen am 07.08.2020
• Titel Quelle: Enthalten in: Molecular cancer
• Ort Quelle: London : Biomed Central, 2002
• Jahr Quelle: 2014
• Band/Heft Quelle: 13(2014,1) Artikel-Nummer 221, 15 Seiten
• ISSN Quelle: 1476-4598
• DOI: doi:10.1186/1476-4598-13-221
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1726645681

Abstract

Cancer cells in the advanced stage show aberrant antioxidant capacity to detoxify excessive ROS resulting in the compensation for intrinsic oxidative stress and therapeutic resistance. PDAC is one of the most lethal cancers and often associated with a high accumulation of ROS. Recent studies identified gold(I) NHC complexes as potent TrxR inhibitors suppressing cell growth in a wide spectrum of human malignant cell lines at the low micromolar concentration. However, the mechanism of action is not completely elucidated yet.