Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Tinoush, Boshra [VerfasserIn]   i
 Shirdel, Iman [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
Titel:Phytochemicals
Titelzusatz:potential lead molecules for MDR reversal
Verf.angabe:Boshra Tinoush, Iman Shirdel and Michael Wink
E-Jahr:2020
Jahr:19 June 2020
Umfang:35 S.
Teil:volume:11
 year:2020
 extent:35
Fussnoten:Gesehen am 10.08.2020
Titel Quelle:Enthalten in: Frontiers in pharmacology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2020
Band/Heft Quelle:11(2020) Artikel-Nummer 832, 35 Seiten
ISSN Quelle:1663-9812
Abstract:Multidrug resistance (MDR) is one of the main impediments in the treatment of cancers. MDR cancer cells are resistant to multiple anticancer drugs. One of the major mechanisms of MDR is the efflux of anticancer drugs by ABC transporters. Increased activity and overexpression of these transporters are important causes of drug efflux and, therefore, resistance in cancer chemotherapy. Overcoming MDR is a fundamental prerequisite for developing an efficient treatment of cancer. To date, various types of ABC transporter inhibitors have been employed but no effective anticancer drug is available at present, which can completely overcome MDR. Phytochemicals can reverse MDR in cancer cells via affecting the expression or activity of ABC transporters, and also through exerting synergistic interactions with anticancer drugs by addressing additional molecular targets. In this review, we summarized numerous phytochemicals that can affect the expression and activity of ABC transporters in MDR cancer cell lines. Phytochemicals in the groups of flavonoids, alkaloids, terpenes, carotenoids, stilbenoids, lignans, polyketides, and curcuminoids have been examined for MDR-reversing activity. The use of MDR-reversing phytochemicals with low toxicity to human in combination with effective anticancer agents may result in the successful treatment of chemotherapy-resistant cancer. In this review, we summarize and discuss the published evidence for plant natural products or secondary metabolites which can modulate MDR.
DOI:doi:10.3389/fphar.2020.00832
URL:Kostenfrei: Volltext ; Verlag: https://doi.org/10.3389/fphar.2020.00832
 Kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fphar.2020.00832/full
 DOI: https://doi.org/10.3389/fphar.2020.00832
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ABC-transporter
 Cancer
 drug efflux
 Multidrug resisitance
 P-Glycoprotein
 secondary metabolites
 Synergism
K10plus-PPN:1726670066
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68625994   QR-Code
zum Seitenanfang