Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Rottensteiner-Brandl, Ulrike [VerfasserIn]   i
 Sarker, Bapi [VerfasserIn]   i
 Heusinger, Dominik [VerfasserIn]   i
 Dafinova, Diana [VerfasserIn]   i
 Rath, Subha N. [VerfasserIn]   i
 Beier, Justus [VerfasserIn]   i
 Kneser, Ulrich [VerfasserIn]   i
 Horch, Raymund [VerfasserIn]   i
 Detsch, Rainer [VerfasserIn]   i
 Boccaccini, Aldo R. [VerfasserIn]   i
 Arkudas, Andreas [VerfasserIn]   i
Titel:In vitro and in vivo biocompatibility of alginate dialdehyde/gelatin hydrogels with and without nanoscaled bioactive glass for bone tissue engineering applications
Verf.angabe:Ulrike Rottensteiner, Bapi Sarker, Dominik Heusinger, Diana Dafinova, Subha N. Rath, Justus P. Beier, Ulrich Kneser, Raymund E. Horch, Rainer Detsch, Aldo R. Boccaccini, and Andreas Arkudas
E-Jahr:2014
Jahr:6 March 2014
Umfang:18 S.
Fussnoten:Gesehen am 12.08.2020
Titel Quelle:Enthalten in: Materials
Ort Quelle:Basel : MDPI, 2008
Jahr Quelle:2014
Band/Heft Quelle:7(2014), 3, Seite 1957-1974
ISSN Quelle:1996-1944
Abstract:In addition to good mechanical properties needed for three-dimensional tissue engineering, the combination of alginate dialdehyde, gelatin and nano-scaled bioactive glass (45S5) is supposed to combine excellent cellular adhesion, proliferation and differentiation properties, good biocompatibility and predictable degradation rates. The goal of this study was to evaluate the in vitro and in vivo biocompatibility as a first step on the way to its use as a scaffold in bone tissue engineering. In vitro evaluation showed good cell adherence and proliferation of bone marrow derived mesenchymal stem cells seeded on covalently crosslinked alginate dialdehyde-gelatin (ADA-GEL) hydrogel films with and without 0.1% nano-Bioglass® (nBG). Lactate dehydrogenase (LDH)- and mitochondrial activity significantly increased in both ADA-GEL and ADA-GEL-nBG groups compared to alginate. However, addition of 0.1% nBG seemed to have slight cytotoxic effect compared to ADA-GEL. In vivo implantation did not produce a significant inflammatory reaction, and ongoing degradation could be seen after four weeks. Ongoing vascularization was detected after four weeks. The good biocompatibility encourages future studies using ADA-GEL and nBG for bone tissue engineering application.
DOI:doi:10.3390/ma7031957
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/ma7031957
 Volltext: https://www.mdpi.com/1996-1944/7/3/1957
 DOI: https://doi.org/10.3390/ma7031957
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:alginate dialdehyde
 biocompatibility
 gelatin
 mesenchymal stem cells
 nano-Bioglass<sup>®</sup>
 tissue engineering
K10plus-PPN:1726815889
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68626648   QR-Code
zum Seitenanfang