Men with negative results of guaiac-based fecal occult blood test have higher prevalences of colorectal neoplasms than women with positive results

• Verfasst von: Brenner, Hermann [VerfasserIn]
• Verfasst von: Hoffmeister, Michael [VerfasserIn]
• Verfasst von: Birkner, Berndt [VerfasserIn]
• Verfasst von: Stock, Christian [VerfasserIn]
• Titel: Men with negative results of guaiac-based fecal occult blood test have higher prevalences of colorectal neoplasms than women with positive results
• Verf.angabe: Hermann Brenner, Michael Hoffmeister, Berndt Birkner and Christian Stock
• Jahr: 2014
• Jahr des Originals: 2013
• Umfang: 8 S.
• Fussnoten: Online 21 November 2013 ; Gesehen am 12.08.2020
• Titel Quelle: Enthalten in: International journal of cancer
• Ort Quelle: Bognor Regis : Wiley-Liss, 1966
• Jahr Quelle: 2014
• Band/Heft Quelle: 134(2014), 12, Seite 2927-2934
• ISSN Quelle: 1097-0215
• DOI: doi:10.1002/ijc.28618
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Men with negative results of guaiac-based fecal occult blood test have higher prevalences of colorectal neoplasms than women with positive results. - 2014
• Sach-SW: colorectal cancer
• Sach-SW: early detection
• Sach-SW: fecal occult blood test
• Sach-SW: prevalence
• Sach-SW: screening
• K10plus-PPN: 1726826945

Abstract

Guaiac-based fecal occult blood tests (gFOBTs) are the most commonly applied tests for colorectal cancer screening globally but have relatively poor sensitivity to detect colorectal neoplasms. Men have higher prevalences of colorectal neoplasms than women. In case of a positive gFOBT result, participants are referred to colonoscopy, independent of sex. To assess performance of gFOBT in routine screening practice, we assessed age and sex specific prevalences (age groups: 55-59, 60-64, 65-69 and 70-74) of colorectal neoplasms in 182,956 women and men undergoing colonoscopy for primary screening and in 20,884 women and men undergoing colonoscopy to follow-up a positive gFOBT in Bavaria, Germany, in 2007-2009. We conducted model calculations to estimate prevalences among gFOBT negative individuals. Analogous model calculations were performed for women and men tested positive or negative with fecal immunochemical tests. In all age groups (55-59, 60-64, 65-69 and 70-74 years), men undergoing colonoscopy for primary screening had substantially higher prevalences of any colorectal neoplasms and essentially the same prevalences of advanced colorectal neoplasms compared to women undergoing colonoscopy to follow-up a positive gFOBT. Model calculations suggest that men with negative gFOBT likewise have substantially higher prevalences of colorectal neoplasms than gFOBT positive women in each age group. Model calculations further indicate that no such sex paradoxon occurs, and a much clearer risk stratification can be achieved with fecal immunochemical tests. Our findings underline need to move forward from and overcome shortcomings of gFOBT-based colorectal cancer screening.