Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging

• Verfasst von: Kanagasundaram, Thines [VerfasserIn]
• Verfasst von: Kramer, Carsten Sven [VerfasserIn]
• Verfasst von: Boros, Eszter [VerfasserIn]
• Verfasst von: Kopka, Klaus [VerfasserIn]
• Titel: Rhenium and technetium-complexed silicon rhodamines as near-infrared imaging probes for bimodal SPECT- and optical imaging
• Verf.angabe: Thines Kanagasundaram, Carsten S. Kramer, Eszter Boros and Klaus Kopka
• E-Jahr: 2020
• Jahr: June 14, 2020
• Umfang: 5 S.
• Fussnoten: Gesehen am 12.08.2020
• Titel Quelle: Enthalten in: Dalton transactions
• Ort Quelle: London : Soc., 1972
• Jahr Quelle: 2020
• Band/Heft Quelle: 49(2020), 22, Seite 7294-7298
• ISSN Quelle: 1477-9234
• DOI: doi:10.1039/d0dt01084g
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1726831531

Abstract

Fluorescent Si-rhodamines were modified to enable complexation with the Re(i)- and 99mTc(i)-tricarbonyl core. The corresponding complexes exhibit suitable properties as bimodal imaging probes for SPECT- and optical imaging in vitro. Importantly, the novel in- aqueous-solution-stable, functionalized Si-rhodamines retain favourable optical properties after complexation (QY = 0.09, λabs = 654 nm, λem = 669 nm in PBS) and show promising near-infrared optical properties for potential in vivo applications enabling bimodal scintigraphic imaging and optical imaging, e.g. used in radio- and fluorescence-guided tumour resection.