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Status: Bibliographieeintrag

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Verfasst von:Loi, Lisa [VerfasserIn]   i
 Zimmermann, Ferdinand [VerfasserIn]   i
 Görke, Steffen [VerfasserIn]   i
 Korzowski, Andreas [VerfasserIn]   i
 Meißner, Jan-Eric [VerfasserIn]   i
 Deike-Hofmann, Katerina [VerfasserIn]   i
 Stieber, Anne [VerfasserIn]   i
 Bachert, Peter [VerfasserIn]   i
 Ladd, Mark E. [VerfasserIn]   i
 Schlemmer, Heinz-Peter [VerfasserIn]   i
 Bickelhaupt, Sebastian [VerfasserIn]   i
 Schott, Sarah [VerfasserIn]   i
 Paech, Daniel [VerfasserIn]   i
Titel:Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T
Verf.angabe:Lisa Loi, Ferdinand Zimmermann, Steffen Goerke, Andreas Korzowski, Jan-Eric Meissner, Katerina Deike-Hofmann, Anne Stieber, Peter Bachert, Mark Edward Ladd, Heinz-Peter Schlemmer, Sebastian Bickelhaupt, Sarah Schott, Daniel Paech
E-Jahr:2020
Jahr:24 May 2020
Umfang:9 S.
Fussnoten:Gesehen am 13.08.2020
Titel Quelle:Enthalten in: European journal of radiology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1990
Jahr Quelle:2020
Band/Heft Quelle:129(2020), Artikel-ID 109068, Seite 1-9
ISSN Quelle:1872-7727
Abstract:Purpose - To investigate whether fat-corrected and relaxation-compensated amide proton transfer (APT) and guanidyl CEST-MRI enables the detection of signal intensity differences between breast tumors and normal-appearing fibroglandular tissue in patients with newly-diagnosed breast cancer. - Method - Ten patients with newly-diagnosed breast cancer and seven healthy volunteers were included in this prospective IRB-approved study. CEST-MRI was performed on a 7T-whole-body scanner followed by a multi-Lorentzian fit analysis. APT and guanidyl CEST signal intensities were quantified in the tumor and in healthy fibroglandular tissue after correction of B0/B1-field inhomogeneities, fat signal contribution, T1- and T2-relaxation; signal intensity differences of APT and guanidyl resonances were compared using Mann-Whitney-U-tests. Pearson correlations between tumor CEST signal intensities and the proliferation index Ki-67 were performed. - Results - APT CEST signal in tumor tissue (6.70±1.38%Hz) was increased compared to normal-appearing fibroglandular tissue of patients (3.56±0.54%Hz, p=0.001) and healthy volunteers (3.70±0.68%Hz, p=0.001). Further, a moderate positive correlation was found between the APT signal and the proliferation index Ki-67 (R2=0.367, r=0.606, p=0.11). Guanidyl CEST signal was also increased in tumor tissue (5.24±1.85%Hz) compared to patients’ (2.42±0.45%Hz, p=0.006) and volunteers’ (2.36±0.54%Hz, p<0.001) normal-appearing fibroglandular tissue and a positive correlation with the Ki-67 level was observed (R2=0.365, r=0.604, p=0.11). APT and guanidyl CEST signal in normal-appearing fibroglandular tissue was not different between patients and healthy volunteers (p=0.88; p=0.93). - Conclusion - Relaxation-compensated and fat-corrected CEST-MRI allowed a non-invasive differentiation of breast cancer and normal-appearing breast tissue. Thus, this approach represents a contrast agent-free method that may help to increase diagnostic accuracy in MR-mammography.
DOI:doi:10.1016/j.ejrad.2020.109068
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.ejrad.2020.109068
 Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X20302576
 DOI: https://doi.org/10.1016/j.ejrad.2020.109068
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:7 Tesla MRI
 APT CEST
 AREX
 Breast cancer
 Fat-correction
 Guanidyl CEST
K10plus-PPN:1726987779
Verknüpfungen:→ Zeitschrift

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