| Online-Ressource |
Verfasst von: | Loi, Lisa [VerfasserIn]  |
| Zimmermann, Ferdinand [VerfasserIn]  |
| Görke, Steffen [VerfasserIn]  |
| Korzowski, Andreas [VerfasserIn]  |
| Meißner, Jan-Eric [VerfasserIn]  |
| Deike-Hofmann, Katerina [VerfasserIn]  |
| Stieber, Anne [VerfasserIn]  |
| Bachert, Peter [VerfasserIn]  |
| Ladd, Mark E. [VerfasserIn]  |
| Schlemmer, Heinz-Peter [VerfasserIn]  |
| Bickelhaupt, Sebastian [VerfasserIn]  |
| Schott, Sarah [VerfasserIn]  |
| Paech, Daniel [VerfasserIn]  |
Titel: | Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T |
Verf.angabe: | Lisa Loi, Ferdinand Zimmermann, Steffen Goerke, Andreas Korzowski, Jan-Eric Meissner, Katerina Deike-Hofmann, Anne Stieber, Peter Bachert, Mark Edward Ladd, Heinz-Peter Schlemmer, Sebastian Bickelhaupt, Sarah Schott, Daniel Paech |
E-Jahr: | 2020 |
Jahr: | 24 May 2020 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 13.08.2020 |
Titel Quelle: | Enthalten in: European journal of radiology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1990 |
Jahr Quelle: | 2020 |
Band/Heft Quelle: | 129(2020), Artikel-ID 109068, Seite 1-9 |
ISSN Quelle: | 1872-7727 |
Abstract: | Purpose - To investigate whether fat-corrected and relaxation-compensated amide proton transfer (APT) and guanidyl CEST-MRI enables the detection of signal intensity differences between breast tumors and normal-appearing fibroglandular tissue in patients with newly-diagnosed breast cancer. - Method - Ten patients with newly-diagnosed breast cancer and seven healthy volunteers were included in this prospective IRB-approved study. CEST-MRI was performed on a 7T-whole-body scanner followed by a multi-Lorentzian fit analysis. APT and guanidyl CEST signal intensities were quantified in the tumor and in healthy fibroglandular tissue after correction of B0/B1-field inhomogeneities, fat signal contribution, T1- and T2-relaxation; signal intensity differences of APT and guanidyl resonances were compared using Mann-Whitney-U-tests. Pearson correlations between tumor CEST signal intensities and the proliferation index Ki-67 were performed. - Results - APT CEST signal in tumor tissue (6.70±1.38%Hz) was increased compared to normal-appearing fibroglandular tissue of patients (3.56±0.54%Hz, p=0.001) and healthy volunteers (3.70±0.68%Hz, p=0.001). Further, a moderate positive correlation was found between the APT signal and the proliferation index Ki-67 (R2=0.367, r=0.606, p=0.11). Guanidyl CEST signal was also increased in tumor tissue (5.24±1.85%Hz) compared to patients’ (2.42±0.45%Hz, p=0.006) and volunteers’ (2.36±0.54%Hz, p<0.001) normal-appearing fibroglandular tissue and a positive correlation with the Ki-67 level was observed (R2=0.365, r=0.604, p=0.11). APT and guanidyl CEST signal in normal-appearing fibroglandular tissue was not different between patients and healthy volunteers (p=0.88; p=0.93). - Conclusion - Relaxation-compensated and fat-corrected CEST-MRI allowed a non-invasive differentiation of breast cancer and normal-appearing breast tissue. Thus, this approach represents a contrast agent-free method that may help to increase diagnostic accuracy in MR-mammography. |
DOI: | doi:10.1016/j.ejrad.2020.109068 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ejrad.2020.109068 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0720048X20302576 |
| DOI: https://doi.org/10.1016/j.ejrad.2020.109068 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | 7 Tesla MRI |
| APT CEST |
| AREX |
| Breast cancer |
| Fat-correction |
| Guanidyl CEST |
K10plus-PPN: | 1726987779 |
Verknüpfungen: | → Zeitschrift |
Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T / Loi, Lisa [VerfasserIn]; 24 May 2020 (Online-Ressource)