Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia

• Verfasst von: Alemu, Yihun Mulugeta [VerfasserIn]
• Verfasst von: Awoke, Worku [VerfasserIn]
• Verfasst von: Wilder-Smith, Annelies [VerfasserIn]
• Titel: Determinants for tuberculosis in HIV-infected adults in Northwest Ethiopia
• Titelzusatz: a multicentre case-control study
• Verf.angabe: Yihun Mulugeta Alemu, Worku Awoke, Annalies Wilder-Smith
• E-Jahr: 2016
• Jahr: April 15, 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 13.08.2020 ; Zu diesem Artikel gibt es eine Korrektur (DOI:10.1136/bmjopen-2015-009058corr1), welche sich auf den falsch geschriebenen Namen der Autorin Annelies Wilder-Smith bezieht
• Titel Quelle: Enthalten in: BMJ open
• Ort Quelle: London : BMJ Publishing Group, 2011
• Jahr Quelle: 2016
• Band/Heft Quelle: 6(2016,4) Artikel-Nummer e009058, 6 Seiten
• ISSN Quelle: 2044-6055
• DOI: doi:10.1136/bmjopen-2015-009058
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: PUBLIC HEALTH
• K10plus-PPN: 1727000986

Abstract

Objective The objective of this study was to identify determinants for tuberculosis (TB) among HIV-infected adults in Northwest Ethiopia. - Design Case-control study. - Setting Three hospitals and 10 health centres in Northwest Ethiopia. - Participants A total of 446 individuals consented to participate in the study (150 cases and 296 controls). Cases were HIV-infected adults diagnosed with active TB, and controls were HIV-infected adults without active TB. - Main outcome measure The link between TB and determinants was assessed using logistic regression. Determinants were categorised as sociodemographic, host-related, clinical and environmental. - Results Smoking (adjusted OR (AOR) 5.47; 95% CI 2.26 to 13.22), presence of a TB patient in the family (AOR 2.66; 95% CI 1.25 to 5.66), alcohol consumption (AOR 2.49; 95% CI 1.29 to 4.80) and chewing khat (AOR 2.22; 95% CI 1.11 to 4.41) were independent determinants for increased occurrence of TB. Highly active antiretroviral therapy (HAART) (AOR 0.25; 95% CI 0.13 to 0.51), isoniazid preventive therapy (IPT) (AOR 0.22; 95% CI 0.11 to 0.41) and cotrimoxazole preventive therapy (AOR 0.32; 95% CI 0.19 to 0.55) had a protective effect against TB. - Conclusions HIV-infected adults with substance abuse (tobacco smoking, khat chewing and alcohol) should be prioritised for TB screening. This study reaffirmed that HAART and IPT are some of the best strategies for reducing TB occurrence in HIV-infected adults. These findings provide impetus to intensify tracing of TB household contacts.