| |  Online-Ressource |
|---|
| Verfasst von: | Binnefeld, Michael [VerfasserIn]  |
|---|
| | Fritz, Sandra [VerfasserIn] |
|---|
| | Balzer, Viktor [VerfasserIn] |
|---|
| | Skalická, Veronika [VerfasserIn] |
|---|
| | Witzigmann, Dominik [VerfasserIn] |
|---|
| | Kauczor, Hans-Ulrich [VerfasserIn] |
|---|
| | Fricker, Gert [VerfasserIn] |
|---|
| | Salomon, Johanna J. [VerfasserIn] |
|---|
| Titel: | Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes |
|---|
| Verf.angabe: | Michael Binnefeld, Sandra Fritz, Viktor Balzer, Veronika Skalická, Dominik Witzigmann, Hans-Ulrich Kauczor, Gert Fricker, Johanna J. Salomon |
|---|
| E-Jahr: | 2020 |
|---|
| Jahr: | 06 June 2020 |
|---|
| Umfang: | 10 S. |
|---|
| Fussnoten: | Gesehen am 13.08.2020 |
|---|
| Titel Quelle: | Enthalten in: European journal of pharmaceutics and biopharmaceutics |
|---|
| Ort Quelle: | New York, NY [u.a.] : Elsevier, 1997 |
|---|
| Jahr Quelle: | 2020 |
|---|
| Band/Heft Quelle: | 153(2020), Seite 158-167 |
|---|
| ISSN Quelle: | 1873-3441 |
|---|
| Abstract: | Matrix-Liposomes (MLs) are a very promising solid oral drug delivery system; however, data on their interaction with biological membranes are not available. Here, we describe the quality of MLs manufactured by dual centrifugation. MLs were prepared with a Z-average range of 139 to 160nm and a PDI of 0.18 to 0.25. To investigate the effect of MLs on intestinal tissue (with and without mucolytic treatment), we then established an ex vivo rat intestine model. The integrity of the epithelial membranes of rat intestine was not affected by the incubation with MLs without or with pre-mucolytic treatment. Tissue samples were also analysed for changes in P-glycoprotein (P-gp) expression and function. The net secretion of the P-gp substrate Rh123 across the rat duodenum was increased in the presence of MLs. To summarize, MLs do not affect intestinal epithelial integrity, although they impact Rh123 secretion. In future, these novel MLs have to be further evaluated for proficient intestinal drug delivery. |
|---|
| DOI: | doi:10.1016/j.ejpb.2020.06.001 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ejpb.2020.06.001 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0939641120301600 |
|---|
| | DOI: https://doi.org/10.1016/j.ejpb.2020.06.001 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Drug transporters |
|---|
| | Dual centrifugation |
|---|
| | Intestine |
|---|
| | Liposomes |
|---|
| | Oral peptide drug delivery |
|---|
| | Ussing Chamber |
|---|
| K10plus-PPN: | 1727012712 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes / Binnefeld, Michael [VerfasserIn]; 06 June 2020 (Online-Ressource)
