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Status: Bibliographieeintrag

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Verfasst von:Brands, Roman C. [VerfasserIn]   i
 Scheurer, Mario J. J. [VerfasserIn]   i
 Hartmann, Stefan [VerfasserIn]   i
 Seher, Axel [VerfasserIn]   i
 Freudlsperger, Christian [VerfasserIn]   i
 Moratin, Julius [VerfasserIn]   i
 Linz, Christian [VerfasserIn]   i
 Kübler, Alexander [VerfasserIn]   i
 Müller-Richter, Urs [VerfasserIn]   i
Titel:Sensitization of head and neck squamous cell carcinoma to apoptosis by combinational SMAC mimetic and Fas ligand-Fc treatment in vitro
Verf.angabe:Roman C. Brands, Mario J.J. Scheurer, Stefan Hartmann, Axel Seher, Christian Freudlsperger, Julius Moratin, Christian Linz, Alexander C. Kübler, Urs D.A. Müller-Richter
E-Jahr:2020
Jahr:2 June 2020
Umfang:9 S.
Fussnoten:Gesehen am 13.08.2020
Titel Quelle:Enthalten in: Journal of cranio-maxillofacial surgery
Ort Quelle:Oxford [u.a.] : Elsevier, 1987
Jahr Quelle:2020
Band/Heft Quelle:48(2020), 7, Seite 685-693
ISSN Quelle:1878-4119
Abstract:This study aimed to investigate the in vitro efficacy of three different SMAC mimetics for pro-apoptotic sensitization of HNSCC cells. We evaluated BV-6 in comparison to Birinapant and LCL161, for which pro-apoptotic sensitization effects have been demonstrated. Concentration-dependent response was measured for BV-6 in each cell line with an average IC50 value 8-fold lower than of aforementioned SMAC mimetics. Combination treatment of FasL (log2) and BV-6 (IC10) showed highly significant cell count reductions even in the lowest applied concentration in five cell lines (PCI-1: p = 0.0002, PCI-13: p = 0.0002, Detroit 562: p: p < 0.0001, FaDu: p < 0.0001, SCC-25: p = 0.0047). Synergistic effects (y < 1) were evident in eight out of 10 cell lines (PCI-1, PCI-9, PCI-13, PCI-68, Detroit 562, FaDu, SCC-25 and HaCaT). Annexin V assays revealed in nine cell lines very highly significant (p < 0.001) pro-apoptotic effects of BV-6. Western blots showed a heterogeneous IAP expression following SMAC mimetic treatment. Except for two cell lines, at least the cellular inhibitor of apoptosis protein 1 (cIAP1) was degraded in response to BV-6. For prospective targeted HNSCC therapy, this study identifies SMAC mimetics, particularly BV-6 as the compound with the highest pro-apoptotic potency, as promising antitumor agents.
DOI:doi:10.1016/j.jcms.2020.05.007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jcms.2020.05.007
 Volltext: http://www.sciencedirect.com/science/article/pii/S1010518220301281
 DOI: https://doi.org/10.1016/j.jcms.2020.05.007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Apoptosis
 BV-6
 FasL
 IAP
 Sensitization
 SMAC mimetics
K10plus-PPN:1727016033
Verknüpfungen:→ Zeitschrift

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